摘要
目的:观察五红汤对乳腺癌化疗后骨髓抑制及生活质量的改善作用。方法:选取103例乳腺癌改良根治术后化疗且并发骨髓抑制的患者为研究对象,根据入院单双号分成研究组和对照组。2组均予化疗,对照组予以常规对症治疗方案,研究组采用五红汤口服。比较2组患者的不良反应发生情况,记录治疗前后中医证候积分、生活质量评估结果及白细胞计数(WBC)、血小板计数(BPC)、血红蛋白(Hb)等骨髓抑制指标变化情况。结果:治疗前,2组中医证候积分及各骨髓抑制指标比较,差异均无统计学意义(P>0.05)。治疗后,2组中医证候积分均较治疗前降低,WBC、Hb及BPC均较治疗前提升,其中研究组各指标改善情况均优于对照组,差异均有统计学意义(P<0.05)。治疗后,2组SF-36评分中除躯体疼痛评分同治疗前比较无统计学差异外,其余7项维度的评分及KPS评分均较治疗前提升,研究组评分均高于对照组,差异均有统计学意义(P<0.05)。研究组无不良反应病例,对照组不良反应发生率为7.8%,2组比较,差异有统计学意义(P<0.05)。结论:对化疗后并发骨髓抑制的乳腺癌患者予以五红汤口服,疗效确切,可有效改善患者的骨髓抑制症状,有利于患者的预后和提升生活质量。
Objective: To investigate the effect of Wuhong Tang on the quality of life and myelosuppression in breast cancer patients after chemotherapy. Methods: One hundred and three breast cancer patients, who received breast modified radical postoperative chemotherapy and concurrent myelosuppression, according to the admission of odd and even numbers, were divided into two groups. The treatment group was treated with Wuhong Tang, and the control group received routine symptomatic therapy. The adverse reaction incidence, and Chinese Medicine(CM) syndrome scores before and after the treatment, quality of life, and myelosuppression index, such as white blood cell(WBC), platelet(PLT), hemoglobin(HBG) were detected. Results: After treatment, the CM syndrome scores of both groups were significantly lower than those before treatment (P 〈 0.05). The index of WBC, HBG and PLT after treatment were improved(P 〈 0.05 compared with before treatment). The differences between the two groups were statistically significant(P 〈 0.05). After treatment, except for Blood Pressure (BP), the other seven index in SF-36 scale and Karnofsky (KPS) scores in both groups were improved (P 〈 0.05compared with before treatment), and the improvement of the treatment group were more significant than that in the control group(P 〈 0.05). No adverse reaction was found in the treatment group, and adverse reaction rate was 7.8% in the control group, the difference being significant(P 〈 0.05). Conclusion: To patients with breast cancer, who concurrent bone marrow suppression after chemotherapy, Wuhong Tang can effectively improve symptoms, and the quality of life.
出处
《新中医》
CAS
2015年第10期171-173,共3页
New Chinese Medicine
关键词
乳腺癌
化疗
骨髓抑制
五红汤
生活质量
Breast cancer
Chemotherapy
Myelosuppression
WuhongTang
Quality of life