血清CEA、Tg联合检测在甲状腺良、恶性肿瘤中的临床价值

The Clinical Value of CEA and Tg Testing in Benign and Malignant Thyroid Tumors Patients

目的探索血清CEA、Tg联合检测在甲状腺良、恶性肿瘤中的临床价值。方法采用化学发光法分别检测经病理证实的68例分化型甲状腺癌(DTC)术前和手术联合131I清甲治疗后、65例甲状腺腺瘤、55例正常对照的CEA、Tg水平,并将结果应用SPSS13.0软件进行统计学分析。结果术前DTC组的CEA水平明显高于腺瘤组(P<0.05)、Tg水平与腺瘤组差异无统计意义(P>0.05);DTC组患者手术联合131I清甲治疗后的Tg水平有显著性下降(P<0.05);术后I和II期DTC患者的Tg、CEA水平明显低于III和IV期的(P<0.05)。结论血清CEA、Tg联合检测对手术及131I清甲治疗后DTC患者的治疗效果及预后判断有较大价值,CEA检测对确诊中晚期的DTC患者有辅助诊断作用。

Objective To investigate the clinical value of combination detection of serum Tg and CEA in benign and malignant thyroid tumors. Methods The serum Tg and CEA were measured with electrochemiluminesence immunoassay for 68 differentiated thyroid carcinoma before surgery and after thyroidectomy followed by 131I treatment. The serum Tg and CEA were also measured for 65 thyroid neoplasm patients, and 55 health subjects as the control separately. The levels of Tg and CEA were statistic analyzed with SPSS13.0 software. Results The level of serum CEA in DTC before surgery were significantly higher than benign thyroid tumors （ P 〈 0.05 ） , however there were no significant difference of Tg between DTC and the benign in DTC was significantly decreased after 13iI treatment. The serum CEA and carcinoma were also significantly difference, the serum CEA and Tg in stage thyroid tumors. The levels of Tg Tg in different stages of thyroid I and II of thyroid carcinoma is significant lower than those in stage Ⅲ and Ⅳ （P 〈 0.05 ）. Conclusion The combination detection of serum CEA and Tg is a great value in evaluating the 131I treatment effect and predicting the prognosis of DTC. The examination of CEA is also an important auxiliary diagnostic method for advanced DTC patients.