摘要
目的 通过滋阴补肾法观察滋阴补肾汤方对体外受精—胚胎移植（IVF-ET）过程中肾阴亏虚型卵巢储备功能下降的干预作用。方法 对肾阴亏虚型卵巢储备功能下降而暂缓体外受精—胚胎移植（IVF-ET）治疗的患者随机分为中药滋阴补肾汤方组（30例）和西药屈螺酮炔雌醇片组（30例）,治疗3个月经周期,治疗前后月经周期第2~5天分别测量血清基础卵泡刺激素（FSH）、基础黄体生成素（LH）、基础雌二醇（E2）、苗勒管素（AMH）,并于治疗前后月经第5天阴道B超监测卵巢窦卵泡（AFC）变化情况。结果 1中药组治疗后血FSH水平及FSH/LH比值较治疗前降低（P〈0.01）,AMH水平较治疗前升高,而且在降低FSH/LH水平及升高AMH方面优于西药组;2窦卵泡数的改善与年龄阶段有相关性,年龄越大,治疗效果越不显著,对于低、中年龄段,中药对窦卵泡数治疗效果显著。结论 滋阴补肾汤可以通过调节血清激素水平改善肾阴亏虚型卵巢储备功能下降患者卵巢储备功能,提高IVF-ET的成功率。
Objective To observe the effect of Ziyin Bushen Decoction on ovarian reserve function in patients with in vitro fertilization embryo transfer （IVF-ET） in the process of kidney yin deficiency diminished ovarian reserve intervention. Methods The patients with ovarian reserve function decreased and suspension in vitro fertilization embryo transfer treatment were randomly assigned to Chinese medicine of Ziyin Bushen Decoction group （30 cases ） and Western medicine Qu drospirenone ethinyl estradiol tablets group （30 cases ）. The treatment was carried out for three menstrual cycles. The serum levels of follicle stimulating hormone （FSH） , luteinizing hormone （LH）, estradiol （E2 ）, and Mullerian tube hormone （AMH） in patients at 2-5 days before and after the treatment of menstrual cycle were detected. The vaginal ultrasound monitoring of ovarian antra1 bubble （AFC） were carried out at 5th day of before and after the treatment of menstrual cycle. Results The serum levels of FSH and FSH to LH ratio Chinese medicine treatment group were significantly lower than those in the western medicine group （ P 〈 0.01 ）, and the AMH level was significantly higher than that in the western medicine group. The improvement of FSH to LH ratio and AMH were significantly higher than that in western medicine. Conclusion Ziyin Bushen Decoction could improve the ovarian reserve function of patients who suffer from kidney yin deficiency by adjusting the serum hormone level and increase the success rate of IVF-ET.
出处
《标记免疫分析与临床》
CAS
2015年第9期856-858,883,共4页
Labeled Immunoassays and Clinical Medicine
