应用ROC曲线分析降钙素原在细菌性肺炎中的诊断价值

Value of Procalcitonin in the Diagnosis of Bacterial Pneumonia

目的探讨降钙素原在细菌性肺炎中的诊断价值。方法分别测定89例细菌性肺炎患者和53例健康志愿者的降钙素原、C反应蛋白及WBC水平,应用ROC曲线分析降钙素原诊断细菌性肺炎的最佳阈值、灵敏度、特异度、准确度、阳性预测值和阴性预测值。结果病例组降钙素原水平明显高于对照组,差异有统计学意义(P<0.05);ROC曲线分析降钙素原诊断细菌性肺炎的曲线下面积为0.968,灵敏度95.0%,特异度85.7%,准确度为87.7%,阳性预测值为89.4%,阴性预测值为93.1%。结论降钙素原在细菌性肺炎的诊断中具有较高的灵敏度和特异度,是细菌性肺炎较特异的血清学标志物。

Objective To study the diagnostic value of the procalcitonin in the bacterial pneumonia. Methods The serum procalcitonin, C-reactive protein and white blood cell （WBC） level in 89 patients with bacterial pneumonia and 53 healthy volunteers were detected, then the optimal threshold, sensitivity, specificity, accuracy, positive and negative predictive value were analyzed by using ROC curves. Results The serum procalcitonin levels in patients with bacterial pneumonia were significantly higher than that of controls （P 〈 0.05 ）. The ROC curves analysis results indicated that the area under curve was 0.968, the sensitivity of procalcitonin diagnosis was 95.0%, specificity was 85.7%, accuracy degree was 87.7%, positive predictive value was 89.4%, negative predictive value was 93.1%. Conclusion The serum procalcitonin might be used as specific index to in the diagnosis of bacterial pneumonia with the high sensitivity and specificity.