^(131)I治疗初诊Graves甲亢并白细胞减少618例疗效分析

Curative Effect Analysis of ^(131)I in the Treatment of 618 First Examined Graves' Hyperthyroidism with WBC Loss Patients

目的分析初诊Graves甲亢并白细胞(white blood cells,WBC)减少的131I治疗疗效。方法对我院2001年7月至2013年12月经131I治疗初诊Graves甲亢并WBC减少患者随访的618例进行回顾性分析。结果初诊Graves甲亢并WBC减少的女性患者的WBC低于男性患者(P<0.05)。131I治疗:甲亢治疗治愈率(包括甲减)95.31%(589/618),好转率4.69%(29/618),甲减率6.9%(43/618),有效率达100%(618/618);甲亢治愈的同时,WBC减少治愈率95.63%(591/618),治疗前后WBC水平差异有统计学意义F=20292.06,P=0.000;4.37%(27/618)患者WBC仍低于正常(3.68±0.38×109/L),但比较其初诊时WBC(2.97±0.56×109/L)水平呈明显升高(P<0.05)。结论131I治疗初诊Graves甲亢并WBC减少患者的甲亢和WBC的治愈率高,有效率达100%,初诊Graves甲亢并WBC减少的患者应首选131I治疗。

Objective To analysis the 131I curative effect of first examined Graves＇ hyperthyroidism with White blood cells （WBC） loss patients. Methods Retrospectively investigation of 618 first examined Graves＇ hyperthyroidism with WBC loss patients, who were treated with 131I were carried out and follow-up. Results Among the first examined Graves＇ hyperthyroidism with WBC loss patients,the WBC of females was lower than that of males （ P 〈 0.05 ）. After 131I treatment, the cure rate of hyperthyroidism （ including hypothyroidism） was 95.31% and the improvement rate was 4.69%. The rate of hypothyroidism was 6.9%. The effective rate was 100%. After the hyperthyroidism was cured,the cure rate of WBC was 95.63%. The WBC level in 4.37% patients was lower than normal levels, but it was significantly increased compared to the initial WBC levels （ P 〈0. 05）. Conclusion The cure rate of first examined Graves＇ hyperthyroidism with WBC loss patients with 131I treatment was high with 100% effective rate. The first examined Graves＇ hyperthyroidism with WBC loss patients should be preferred to use 131I treatment.