DC-CIK细胞治疗联合伽玛刀治疗局部晚期肝癌的近期疗效观察

Short-term effect of combined treatment of DC-CIK cell and Gamma knife ON locally advanced hepatic carcinoma

目的:研究树突状细胞和细胞因子诱导的杀伤细胞(DC-CIK)过继免疫疗法联合伽玛刀治疗中晚期肝癌的临床疗效及意义。方法:选择42例中晚期原发性肝癌患者,随机分为两组:联合组20例,给予DC-CIK细胞过继免疫治疗及体部伽玛刀放疗;对照组22例,仅接受体部伽玛刀放疗,比较两组治疗后的近期疗效、生存质量、生存期及毒副反应。结果:治疗后3个月,联合组与对照组的近期疗效分别为70%、54.5%(P<0.05),联合组中生存期、T细胞亚群变化、PS评分、AFP下降率、肝功能分级等均优于对照组,Ⅱ度及以上放射性皮炎、骨髓抑制等联合组也好于对照组。结论:DC-CIK细胞过继免疫疗法联合伽玛刀治疗中晚期肝癌能延长患者生存期,改善生活质量,减少毒副反应,有效提高近期临床疗效。

Objective： To explore the effect of adoptive immunotherapy of dendritic cell and cytokine-induced killer cell （DC-CIK） combined with the gamma knife on the treatment of middle and advanced hepatic carcinoma. Methods： A total of 42 patients with the middle and advanced primary hepatic carcinoma were randomly divided into two groups： 20 cases in the combination group were given the adoptive immunotherapy of DC-CIK cells and gamma knife radiotherapy; 22 cases in the control group were only given the gamma knife radiotherapy. The short-term effect, quality of life, overall survival and toxic and side effects were compared between two groups after the operation. Results： Three months after the treatment, the short-term effect of combination group and control group was significantly difference （P〈0.05）. The overall survival, change of T-cell subsets, PS score, decrease rate of AFP and degree of liver function combination group were superior than the control group, while the adiodermatitis at II and over and bone marrow suppression were also better than the control group. Conclusion： The adoptive immunotherapy of DC-CIK ceils combined with the gamma knife in the treatment of middle and advanced hepatic car- cinoma can prolong the overall survival, improve the quality of life, reduce the toxic and side effect and effectively promote the short-term clinical effect for patients.