四种常用抗球虫药对兔场球虫病的疗效比较

The efficacies of four common anticoccidiai medicines against rabbit coccidiosis

为比较4种常用抗球虫药防治兔场球虫病的防治效果，将50日龄的60只兔随机分成6组，即不感染不用药组（I组），感染不用药组（Ⅱ组），氯苯胍组（Ⅲ组），磺胺氯达嗪组（Ⅳ组），地克珠利组（V组），妥曲珠利组（Ⅵ组）。每组10只。除I组外，其余各组兔按每100g体重灌服5x104个球虫卵囊。根据临床症状、病理变化、增重和OPG、饲料转化率等指标进行疗效判定。结果表明．妥曲珠利和磺胺氯哒嗪能有效抑制球虫卵囊的排出，降低幼兔死亡率，增加兔只体重，而氯苯胍和地克珠利防治效果差。与感染不用药对照组无明显差异．说明氯苯胍和地克珠利不能长期使用．需将筛选的高效安全抗球虫药用于兔球虫病的防治。

In order to compare the efficacies of diclazuril,robennidine,sulfachlorpyridazine,and tohrazurilagainst rabbit coccidiosis,sixisty rabbits were randomly grouped into uninfected and unmedicated treatment（Ⅰ）, infected and unmedicated treatment（Ⅱ）, robennidine treatment（Ⅲ）, diclazuril treatment（V）, sulfachlor-pyridazine treatment （Ⅳ）,tohrazuril treatment （VI）.The 5x104 coccidian oocysts per 100g weight of rabbitwere used to artificially infect II, HI. IV. V and VI test groups, and then treated them from second-day.The efficacies were assessed by the dates of symptoms, pathological changes, weight gains and OPG.The re-suits indicated that sulfachlorpyridazine and tohrazuril were more effective than diclazuril or robennidine inreducing oocyst output, coccidosis mortality and body-weight gain increasing. The efficacies of robennidineand diclazuril were very poor, and had little difference from group I1. It was concluded that robennidineand diclazuril were not fit to be used for long time, and the highly effective medicine that were choosedfrom clinical tests should be used to control the rabbit coccidiosis.