前房内给予莫西沙星预防眼内炎在白内障手术中的应用（英文）

Application of intracameral moxifloxacin to prevent endophthalmitis in cataract surgery

目的：评价在白内障手术中采用前房内应用莫西沙星预防眼内炎的安全性和效果。 方法：选取2012年1-6 mo在我院行白内障手术患者65例65眼。部分患者手术结束时前房给予莫西沙星,另外一部分作为对照组未使用莫西沙星。对患者术前和术后logMAR最佳矫正视力、眼内压、角膜水肿、前房形态进行检查。 结果：共33例患者（男19,女14）使用了莫西沙星,平均年龄64.81±11.61（41~82）岁；32例患者（男15,女17）没有使用,平均年龄65.43±11.10（42-81）岁。患者的年龄（P=0.827）和性别（P=0.396）无统计学差异。术前两组的最佳矫正视力均接近20/130。术后,莫西沙星组和对照组的最佳矫正视力分别为20/25和20/23（ P=0.160）。术前莫西沙星组眼内压为14.93±2.77（11-21） mmHg,对照组为15.06±2.42（12-21）mmHg（P=0.850）。术后,两组眼内压均无统计学差异[莫西沙星组：14.06±2.31（10-19） mmHg；对照组：14.03±2.36（10-19） mmHg （ P=0.726）]。两组角膜水肿（P=0.623）与前房细胞发生率（P=0.726）均无统计学差异。 结论：白内障手术后给予莫西沙星预防眼内炎是安全而有效的。

AIM：To evaluate the safety and efficacy of intracameral moxifloxacin in preventing endophthalmitis after cataract surgery. METHODS：Sixty-five eyes of 65 patients underwent cataract surgery between January and June 2012. Some patients received intracameral moxifloxacin at the end of surgery, while others did not （ controls ） . Pre - and postperative logarithm of the minimum angle of resolution （ logMAR ） best corrected visual acuity （ BCVA） , intraocular pressure （ IOP） , corneal edema, and anterior chamber （ AC） status were examined. RESULTS： Thirty - three patients （ 19 males, 14 females）; average age, 64. 81±11. 61y （ range： 41-82y） received moxifloxacin and 32 patients （ 15 males, 17 females）; average age, 65. 43±11. 10y （ range： 42-81y） did not. The differences in patient age （P=0. 827） and sex （P= 0. 396） were insignificant. Preoperative BCVA was approximately 20/130 in both groups. After surgery, moxifloxacin and control patients had a BCVA of 20/25 and 20/23, respectively （P=0. 160）. Preoperative IOP was 14. 93±2.77mmHg （ range： 11-21mmHg） in moxifloxacin patients and 15. 06±2. 42mm Hg （ range： 12-21mmHg） in controls （ P = 0. 850 ）. After surgery, IOP was not statistically different between two groups （ moxifloxacin：14. 06±2. 31 （ range： 10-19mmHg）, controls： 14. 03±2. 36mmHg （ range： 10 - 19mmHg ）, P = 0. 960 ）. Slight differences in corneal edema （ P = 0. 623 ） and anterior chamber cell （P=0. 726） incidences between two groups were not statistically significant. CONCLUSION： Intracameral moxifloxacin is safe and effective in preventing endophtalmitis after cataract surgery.