糖尿病大鼠眼内VEGF阶段性表达的Meta分析

Meta analysis of VEGF periodic expression in intraocular tissue of diabetic rats

目的：通过分析确定 VEGF 在糖尿病大鼠眼病各阶段表现,为临床治疗阶段提供最有效的参考。 方法：通过检索PubMed、EMBASE、Medline、中国知网、万方、维普等数据库,筛选以糖尿病大鼠为模型研究VEGF在糖尿病眼病病程中表达的随机对照实验。对入选文献用Jadad评分表（共5分）进行评分,经异质性检验后采用固定效应模型进行数据综合,按时间段进行亚组分析。 结果：纳入高质量文献8篇,异质性检验排除两篇。数据综合显示糖尿病大鼠眼内VEGF的表达上升了1.62%,95%CI（1.20,2.03）,P〈0.01。 结论：VEGF在2~6月龄糖尿病大鼠眼内组织各个阶段中表达增强,但强度在逐渐下降。

AIM：To investigate VEGF expression at various stages of diabetic rats eye disease through Meta analysis and then provide effective reference for clinical treatment. METHODS： The randomized controlled experiment which studied the VEGF expression in the course of diabetic eye disease and used diabetic rat model was screened by searching database including pubmed, EMBASE, Medline, CNKI, Wanfang, VIP. Jadad scale （ 5 points as the full marks） was used to assess the quality of the included literatures. Data synthesis was carried out by the fixed effect model after heterogeneity test. Subgroups were divided according to different experiment stages. RESULTS：Eight high quality literatures were included, two literatures were excluded after heterogeneity test. Data synthesis showed that VEGF expression in intraocular tissue of diabetic rats increased by 1. 62%[95%CI（1. 20~2. 03）,P〈0. 01]. CONCLUSION：VEGF expression in intraocular tissue of diabetic rats is increased in each stage and gradually decreases monthly from two to six months.