更昔洛韦眼用凝胶和阿昔洛韦滴眼液治疗病毒性角膜炎疗效对比

Comparison on the effect of ganciclovir ophthalmic gel and aciclovir eye drops on viral keratitis

目的:探讨病毒性角膜炎应用更昔洛韦眼用凝胶的疗效。方法:随机选择2013-05/2014-10我院收治的84例101眼病毒性角膜炎患者作为研究对象,随机分为更昔洛韦组和对照组,分别给予更昔洛韦眼用凝胶和阿昔洛韦滴眼液治疗,2wk后观察疗效。结果:两组患者治疗后较治疗前病毒性角膜炎各症状(畏光、流泪、疼痛、异物感)及各体征(睫状充血、角膜上皮缺损、角膜基质水肿、角膜荧光素染色)评分均有显著改善,更昔洛韦组改善更为明显(P<0.05);更昔洛韦组有效率(92.9%)明显高于对照组(59.5%),差异有统计学意义(P<0.05);两组患者不良反应无统计学差异(P>0.05),更昔洛韦组复发率明显低于对照组(P<0.05)。结论:更昔洛韦眼用凝胶是一种安全有效的抗病毒滴眼液,治疗病毒性角膜炎疗效确切,值得临床中推广应用。

AIM：To investigate the effect of ganciclovir ophthalmic gel on viral keratitis. METHODS： Eighty- six cases （ 101 eyes ） with viral keratitis in our hospital from May 2013 to October 2014 were randomly selected as the research subjects and were divided into the ganciclovir group and the control group, the patients in ganciclovir group were given ganciclovir ophthalmic gel and those in control group were given aciclovir eye drops. The curative effect were observed after 2wk. RESULTS： After treatment, the symptoms of viral keratitis （ photophobia, tears, pain, foreign body sensation ） and the signs （ ciliary congestion, corneal epithelial defect, corneal stromal edema, corneal fluorescein staining ） scores of the two groups were significantly improved than before treatment, those of ganciclovir group were improved more obviously （ P〈0.05）. The efficiency of the ganciclovir group （92. 9%） was significantly higher than that of the control group （59. 5%） with statistical significance （P〈0. 05）. There was no statistical difference between the two groups of patients with adverse reactions （P〉0. 05）. The recurrence rate of ganciclovir group was significantly lower than that of the control group （P〈0. 05） CONCLUSION： Ganciclovir ophthalmic gel is a safe and effective antiviral eye drops, has exact effect on viral keratitis, and is worth of clinical application.