他汀类药物对冠脉旁路移植术后房颤发生率的影响

Influence of statin on the incidence of atrial fibrillation after coronary artery bypass grafting

目的探讨术前预防性应用他汀类药物是否对冠脉旁路移植术后心房颤动发生率有影响。方法回顾性分析解放军总医院2012年1月~2014年11月单纯冠脉旁路移植术554例患者,根据术前是否应用他汀类药物分为他汀类药物组340例,对照组214例。他汀类药物组至少术前3d开始服用他汀类药物,观察终点为术后直至出院前的区间内,任何需要抗心律失常药物或者减慢心率、负性变时药物或者需要电复律处理的心房颤动。结果他汀类药物组术后35例（10.3%）发生术后房颤,对照组22例（10.3%）,两者差异无统计学意义（P=0.996）。结论术前他汀类药物应用与否对术后心房颤动发生率未见明显影响。

Objective To investigate whether preoperative statin administration affects the incidence of atrial fibrillation after coronary artery bypass grafting. Methods A total of 554 cases received coronary artery bypass grafting alone from Jan 2012 to Nov 2014 were prospectively collected and retrospectively studied. Subjects were divided into 2 groups according to with or without preoperative statin administration. There were 340 cases in statin group while 214 cases in contrast group. Statin ad- ministration began at least 3 days before operation. All cases were followed perioperatively till discharge while any newly oc- curred postoperative atrial fibrillation which required antiarrhythmic drug, negative chronotropic drug or electrical cardioversion were strictly recorded. Results 35 cases （10.3%） suffered postoperative atrial fibrillation in statin group while the same result occurred in 22 cases （10.3%） of contrast group. There were no significant statistical differences of postoperative atrial fibrillation incidence between two groups. Conclusion In this study, there are no significant effects of preoperative statin administration on postoperative atrial fibrillation incidence of coronary artery bypass grafting.