血清肿瘤标志物的联合检测在原发性肝癌中的诊断价值

Clinical Value of Combined Detection of Serum Tumor Markers in Diagnosis of Primary Hepatocellular Carcinoma

目的探讨血清甲胎蛋白(AFP)、癌胚抗原(CEA)、癌抗原125(CA125)、CA199的联合检测在原发性肝癌(PHC)中的诊断价值。方法选取我院收治的72例PHC患者(PHC组)、80例良性肝病患者(良性肝病组),另选取同期100例体检健康者(对照组),采用化学发光法分别检测所有研究对象的血清AFP、CEA、CA125、CA199水平并进行统计学分析。结果 PHC组血清AFP、CEA、CA125和CA199阳性率均高于良性肝病组与对照组,比较差异均有统计学意义(P<0.05),4项肿瘤标志物联合检测在PHC组的阳性率高于各肿瘤标志物单项检测的阳性率,比较差异均有统计学意义(P<0.05)。结论 AFP、CEA、CA125、CA199联合检测能够提高PHC的诊断阳性率,有助于PHC的早期诊断。

Objective To study the clinical value of the combined detection of the serum levels of AFP、CEA、CA125 and CA199 in the diagnosis of primary hepatocel uar carcinoma（PHC）.Methods The serum levels of AFP、CEA、CA125 and CA199 in 72 cases of PHC（PHC group）,80 cases of benign liver disease（benign liver disease group）and 100 persons of healthy physical examination（control group）were measured by chemiluminescence and the detection results were statistical y analyzed. Results The positive rate of AFP、CEA、CA125 and CA199 in the PHC group were significantly higher than those in the benign liver disease group and control group,with significant dif erences（P〈0.05）,the positive rate of 4 item combined detection was significantly higher than that in the single item detection of various tumor markers（P〈0.05）. Conclusion The combined detection of AFP、CEA、CA125 and CA199 could obviously increase the detective positive rate of PHC and could be conducive to early diagnosis of PHC.