探讨早产儿甲状腺功能监测及临床意义

Discussion on Thyroid Function in Preterm Children and Its Clinical Significance

目的分析早产儿甲状腺功能监测及临床意义。方法 120例早产儿,按胎龄分为甲、乙、丙三组,采用放射免疫法对三组新生儿出生后第1、7 d促甲状腺激素(TSH)、游离甲状腺素(FT4)、游离血清三碘甲状腺原氨酸(FT3)水平进行检测和分析。结果出生后1d,甲组和乙组TSH低于丙组,且甲组较乙组TSH水平更低(P<0.05);出生后7d,甲组TSH水平高于乙组和丙组(P<0.05),而乙组和丙组TSH水平比较差异无统计学意义(P>0.05)。结论早产儿出生后易发生甲状腺功能低下,胎龄越小,甲状腺功能越低,出生后应激反应持续时间更长。

Objective To analyze preterm children thyroid function and its clinical significance. Methods 120 cases of preterm children, according to gestational age are divided into A, B, C three groups, by radioimmunoassay for the first three groups after birth 1, 7 d thyroid stimulating hormone （TSH）, free thyroxine （FT4）, free three serum triiodothyronine （FT3） detection and analysis. Results Postnatal ld, TSH Groups A and B were significantly lower than group C and Group A TSH level lower than the group B （P〈0.05）, postnatal 7 d, Group A Group B and Group C TSH levels above （P〈0.05）, while group B and group C TSH level was no significant difference （P〉0.05）. Conclusion Preterm children prone to hypothyroidism after birth, gestational age, the lower thyroid function, after the birth of the stress response lasts lonzer.