右美托咪定与咪达唑仑在插管镇静中的应用对比观察

To Observe the Application of Dexmedetomidine Compared With Midazolam on Sedation During Intubation

目的：对比右美托咪定与咪达唑仑在插管镇静中的应用效果。方法以2014年1月～2014年12月期间80例行全麻经鼻气管插管的患者作为本组的研究对象，按照用药方案将其分为对照组与观察组各40例，对照组给予静脉输注咪达唑仑0.1μg/kg ；观察组给予静脉输注右美托咪定0.6μg/kg，对比两组患者的插管时间、平均动脉压（MAP）与心率（HR）。结果两组插管时间之间比较无明显差异，不具有统计学意义，P ＞0.05。插管前，两组在 MAP 与 HR 之间无明显差异。插管后，观察组的 MAP 与 HR 均低于对照组，具有统计学意义，P ＜0.05。结论在插管镇静中应用右美托咪啶，可以有效稳定患者插管时的血压与心率，其应用效果优于咪达唑仑。

Objective Comparison of dexmedetomidine set with midazolam in intubation sedation application effect. Methods During January 2014 to December 2014, 80 patients undergoing general anesthesia by nasal tracheal intubation as the research object of this group, according to the regimen will the into control group and observation group, each 40 cases, control group was given intravenous infusion of midazolam 0.1 μg/kg midazolam; observation group intravenous infusion of dexmedetomidine 0.6 μg/kg, compared two groups of patients with the intubation time, MAP and HR were measured. Results The intubation time of the observation group and the control group had no significant difference before, not statistically significant, P〉0.05. After intubation, the HR and MAP of the observation group were significantly lower than those of the control group, with statistical significance, P〈0.05. Conclusion In the intubation sedation application of dexmedetomidine, stable and effective intubating a patient＇s blood pressure and heart rate, and its application effect is better than that of the MI of midazolam.