拉米夫定治疗慢性乙肝的效果与药物不良反应观察

Effect of Chronic Hepatitis B Treated by Lamivudine and Observation of Adverse Drug Reactions

目的研究慢性乙肝通过拉米夫定治疗的效果和药物不良反应。方法选取280例慢性乙肝的患者,随机分成两组,对照组进行常规的护肝、对症治疗,观察组在此基础上,用拉米夫定治疗,对比治疗的效果和药物不良反应。结果观察组患者的ALT、ALB、AST、CHE、HBV-DNA定量检测等指标好于对照组,差异有统计学意义,P<0.05,观察组患者不良反应率为9.29%,对照组为12.14%,差异无统计学意义,P>0.05。结论拉米夫定是治疗慢性乙肝的有效药物,可以促进患者肝功能的恢复,不会产生严重的药物不良反应。

Objective To study the effect of chronic hepatitis B and the adverse drug reaction of the treatment of chronic hepatitis B by Mira. Methods A total of 280 cases of patients with chronic hepatitis B were randomly divided into two groups, the control group of conventional Hugan, symptomatic treatment, observe group on the basis of this, with lamivudine treatment, compared to the treatment effects and adverse drug reactions. Results The observation of alt, ALB, AST, CHE, HBV-DNA quantitative detection index of the patient group were better than that of the control group, the difference is statistically significant, P〈0.05, observe the rate of adverse reactions of patients is 9.29%, 12.14% in the control group, the difference was not statistically significant, P〉0.05. Conclusion Lamivudine is an effective drug for treatment of chronic hepatitis B, it can promote the recovery of liver function and can not cause serious adverse drug reactions.