妊娠高血压应用短效与长效硝苯地平的疗效对比分析

Effect Comparison of Short and Long-acting Nifedipine for Pregnancy Patients With Hypertension

目的：分析短效与长效硝苯地平治疗妊娠高血压的疗效差异性。方法连续选取我院2012年2月～2014年2月收治的89例妊娠高血压患者作为研究对象，该研究取得我院伦理委员会通过及患者、家属的知情同意权后，采用随机数字法将患者分为短效硝苯地平组（n=42）及长效硝苯地平组（n=47）。对两组患者治疗后的血压变化情况进行分析，同时观察产妇分娩方式及围生儿结局等情况。结果治疗前两组患者的平均收缩压、平均舒张压和平均动脉压的比较，差异均无统计学意义（P ＞0.05）；治疗后两组患者的平均收缩压、平均舒张压和平均动脉压均下降，且长效组比短效组降低更明显，差异均有统计学意义（P ＜0.05）。结论长效硝苯地平治疗妊娠期高血压具有重要的临床价值，降压效果显著，减少了母婴不良结局的发生。

Objective To study the clinical effect of short and long-acting nifedipine for pregnancy patients with hypertension. Methods A total of 89 consecutives diagnosed as pregnancy with hypertension from February 2012 to February 2014 were divided into short-acting nifedipine group （n=42） and long-acting nifedipine group （n=47） by the random number method after getting approval of our hospital＇ ethics committee and the informed consent right of patients and family members. then to compare differences of the mean systolic pressure, diastolic pressure and mean arterial pressure, the clinical effect and complications rate. Results The mean systolic pressure, diastolic pressure and mean arterial pressure before treatment in the two groups were no statistical difference （P〉0.05）. the mean systolic pressure, diastolic pressure and mean arterial pressure after treatment were all lower than before in the two groups and they in long-acting nifedipine group were significantly lower than short-acting nifedipine group （P〈0.05）. the vaginal delivery rate in the long-acting nifedipine group were significantly higher, the maternal preeclampsia, intrauterine asphyxia, perinatal mortality and fetal adverse outcomes in total incidence rate were in significantly lower than short-acting nifedipine group （P〈0.05）. Conclusion The long-acting nifedipine could greatly improve clinical effect and decrease complications than short-acting nifedipine.