氯吡格雷与阿司匹林治疗老年冠心病的临床疗效对比

Comparison of the Clinical Efficacy of Clopidogrel and Aspirin in the Treatment of Elderly Coronary Heart Disease

目的分析比较阿司匹林与氯吡格雷治疗老年冠心病的临床疗效。方法选择老年冠心病患者96例作为研究对象,按治疗方法的不同,分为对照组(n=48例)和观察组(n=48例),对照组给予单纯阿司匹林治疗,观察组给予氯吡格雷治疗,对两组患者的临床效果进行分析比较。结果两组患者治疗前的PAG、PT、APTT指标比较差异不显著(P>0.05);观察组治疗后的PAG、PT、APTT指标分别为(31.26±5.23)%、(14.38±2.67)s、(40.23±2.34)s,优于对照组与的(43.78±8.43)%、(12.87±1.89)s、(48.51±1.67)s,差异有统计学意义(P<0.05);观察组胃黏膜出血率为4.17%,对照组胃黏膜出血率为12.50%,差异有统计学意义(P<0.05)。结论老年冠心病采取氯吡格雷治疗的临床效果显著,且安全性好。

Objective To analyze the clinical effect of aspirin and clopidogrel in the treatment of coronary heart disease. Methods 96 elderly patients with coronary heart disease （CHD） were divided into control group （n=48） and observation group （n=48 cases）. The control group was treated with aspirin, and the clinical effect of the two groups was analyzed and compared. Results Two groups of patients before treatment, PT, APTT, PAG index were not significantly different （P〉0.05）, PAG, APTT, PT index were （31.26±5.23） %, （14.38±2.67） s, （40.23±2.34） s, better than the control group （43.78±8.43）%, （8.43±12.87） s, （1.89±1.67） s, the difference was statistically significant （P〈0.05）, the control group was 12.50%, the difference was statistically significant （P〈0.05）. Conclusion Elderly patients with coronary heart disease treated with clopidogrel, the clinical effect is significant, and the safety is good.