氨丙基修饰M41作为胰岛素的缓释载体

Aminopropyl Modified M41 as the Sustained Release Carrier of Insulin

通过水热法合成介孔材料M41,并用3-氨丙基三乙氧基硅烷对其进行修饰.将M41和氨丙基修饰M41作为降糖药物胰岛素的载体,获得药物组装体M41-Ins(M/Ins)和氨丙基修饰M41-Ins(AM/Ins).采用Fourier变换红外光谱(FT-IR)、透射电子显微镜(TEM)、粉末X射线衍射(XRD)、扫描电子显微镜(SEM)和77K低温氮气吸附-解吸附技术对样品进行表征,并监测胰岛素在人工模拟体液中的释放行为,测定其释放率.实验结果表明:M41经氨丙基修饰后仍保持典型的六方孔道结构;经修饰后的M41释药更缓慢.

M41 was synthesized by hydrothermal method and modified by 3-aminopropyltriethoxysilane.Both M41 and aminopropyl modified M41 were used as the carriers of insulin,which could reduce blood sugar,to obtain assemblies M41-Ins（M/Ins）and aminopropyl modified M41-Ins（AM/Ins）.The structures of the prepared materials were characterized by Fourier transform infrared spectroscopy（FT-IR）,transmission electron microscopy（TEM）,powder X-ray diffraction（XRD）,scanning electron microscopy（SEM）and low temperature nitrogen adsorption-desorption technique at77 K.The release process of prepared drug sinasimulated body fluid solution was studied and the release rate was determined.The experimental results show that aminopropyl modified M41 also had a typical hexagonal pore structure,with the loading capacity of AM/Ins larger and the drug release rate of AM/Ins was slower than those of M/Ins.