阿立哌唑、喹硫平和利培酮对精神分裂症患者甲状腺素水平的影响

Effect of azole,quetiapine and risperidone on the level of thyroid hormone in patients with schizophrenia

目的:探讨不同药物治疗对精神分裂症患者甲状腺素水平的影响。方法:将120例精神分裂症患者随机分为A、B、C组,阿立哌唑治疗者为A组,喹硫平治疗者为B组,利培酮治疗者为C组,每组40例。对比3组治疗前、治疗1个月后甲状腺素水平变化。结果:3组治疗前三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、游离三碘甲状腺原氨酸(FT3)及游离四碘甲状腺原氨酸(FT4)差异均无统计学意义(P>0.05),治疗1个月后,3组T3、T4、FT3及FT4均明显下降(P<0.01),且均以B组水平最低(P<0.01),A组FT3下降程度明显低于C组(P<0.01),而A组与C组T3、T4和FT4降低程度差异均无统计学意义(P>0.05)。结论:阿立哌唑、喹硫平和利培酮均可降低精神分裂症患者的甲状腺素水平,且以喹硫平降低最为明显。

Objective：To explore the effects of different drug therapy on the thyroid hormone level in patients with schizophrenia. Methods：One hundred and twenty patients with schizophrenia were randomly divided into group A （ treatment with azole ） , group B （treatment with quetiapine） and group C（treatment with risperidone）（40 cases each group）. The thyroid hormone levels in 3 groups between before treatment and after 1 month of treatment were compared. Results：The differences of the levels of three iodine thyroid glycine（T3）,four iodine glycine（T4）,free three iodine thyroid original glycine（FT3） and free iodine thyroid original glycine（FT4） between 3 groups before treatment were not statistically significant（P〉0. 05）. After 1 month of therapy,the levels of T3,T4,FT3 and FT4 in 3 groups obviously decreased（P〈0. 01）,and the lowest in group B（P〈0. 01）,the level of FT3 in group A was significantly lover than group C（P〈0. 01）,and the differences of whose between group A and group C were not statistically significant（P〉0. 05）. Conclusions：Azole,quetiapine and risperidone can reduce the thyroid hormone level in patients with schizophrenia,and the decreasing degree in patients treated with quetiapine is the most obviously.