痰热清注射液联合抗生素治疗呼吸机相关性肺炎(痰热壅肺证)的研究

Research on Treatment of Tanreqing Injection Combined with Antibiotics for Patients with Ventilator Associated Pneumonia(type of TanReYongFei)

目的:探讨痰热清注射液联合抗生素治疗呼吸机相关性肺炎(VAP)(痰热壅肺证)患者的临床疗效。方法:将96例VAP(痰热壅肺证)患者随机分为实验组(51例)对照组(45例),所有患者均常规使用抗生素及支持对症治疗,实验组患者在此基础上给予痰热清注射液20ml静脉滴注,1次/d,疗程10d;比较2组患者的临床疗效、临床肺部感染评分(CPIS)、APACHEⅡ评分、机械通气时间、首次脱机成功率及血浆C反应蛋白(CRP)、降钙素原(PCT)的水平。结果:实验组临床疗效优于对照组(P<0.05);2组患者治疗后CPIS、机械通气时间及血浆CRP、PCT水平比较,差异有显著性(P<0.05),2组患者APACHEⅡ评分和首次脱机成功率比较,差异无显著性(P>0.05)。治疗中不良反应轻微。结论:痰热清注射液联合抗生素治疗VAP(痰热壅肺证)患者较单纯抗生素治疗的临床疗效更佳。

Objective：To investigate the treatment effects of Tanreqing injection combined with antibiotics for patients with ventilator associated pneumonia（VAP）（type of TanReYongFei）.Methods：96VAP patients（type of TanReYongFei）were randomly divided into two groups,experimental group of 51 cases and control group of 45 cases.The cases of control group were treated with antibiotics as well as support therapy.The cases of experimental group were treated with Tanreqing injection（20ml one day）for besides for those therapies as well.The therapy course of both groups was10 days.The result of these therapies,clinic pulmonary infection score（CPIS）,acute physiology and chronic health evaluation Ⅱ（APACHEⅡ）score,days of mechanical ventilation,the rate of successful weaning for the first time,serum level of C reaction protein（CRP）and procalcitonin（PCT）were compared respectively between the two groups.Results：The efficiency of experimental group was superior to that of control group（P〈0.05）.There were significantly differences in CPIS,days of mechanical ventilation,serum level of CRP and PCT between the two groups（P〈0.05）.There were no significantly differences in APACHEⅡ score and he rate of successful weaning for the first time,between the two groups（P〉0.05）.The side effect was low in both groups.Conclusion：The treatment effect of Tanreqing injection combined with antibiotics for VAP patient（type of TanReYongFei）is better than that of using antibiotics only.