二肽基肽酶-4与慢性肝病相关性研究进展

Progress of the correlation between DPP-4 and chronic liver disease

二肽基肽酶-4(dipeptidyl peptidase-4,DPP-4)是以二聚体形式存在的高特异性跨膜丝氨酸蛋白酶,广泛存在于血浆和组织中,主要通过肽酶活性发挥其多效性。目前研究显示DPP-4与机体的免疫刺激、脂肪积累、细胞外基质退化及抑制抗癌剂有关。近年来研究表明,肝脏中DPP-4的表达处于高浓度状态,其参与了各种慢性肝病的发生、发展,如丙肝、非酒精性脂肪肝、肝细胞癌等。本文就DPP-4的生物学效应及其在慢性肝病形成和治疗过程中的作用作一概述。

Dipeptidyl peptidase-4 （DPP-4） is a membrane-associated peptidase, which widely exists in plasma and tissue, primarily displays its peptide enzyme activity through the pleiotropie. DPP-4 is known to be associated with im- mune stimulation, lipid accumulation, degradation of extracellular matrix and resistance to anti-cancer agents. In recent years, DPP-4 expression in the liver is in a state of high concentration, and it is involved in the development of various chronic liver diseases such as hepatitis C virus infection, non-alcoholicfatty liver disease, and hepatocellular carcinoma. In this review, we discussed the impact of DPP-4 in chronic liver disease and the possible therapeutic effects of a DPP- 4 inhibitor.