摘要
目的研究普朗尼克/mPEG-b-PLGA混合胶束中两载体配比对载阿托伐他汀钙聚合物胶束性能的影响。方法制备不同配比的mPEG-b-PLGA、F127载阿托伐他汀钙聚合物混合胶束,用激光粒度分析仪(DLS),稳态荧光光谱仪,紫外分光光度计(UV)等对其粒径、临界胶束浓度、载药量以及体外释放的性质进行了考察。结果混合胶束在载药量、稳定性等方面都由于单一普朗尼克胶束,通过药物体外释放试验比较,在24h时,混合胶束的释放量明显提高,药物更完全的释放。结论在普朗尼克载阿托伐他汀钙胶束的制备中加入一定比例的mPEG-bPLGA可不同程度的提高其性能,具有一定的应用前景。
Objective Research of effect of two carrier Pluronic and mPEG-b PLGA molar ratio on the atorvastatin calcium（ATV）-loaded polymer micelles. Methods Preparation of different ratio of mPEG-b PLGA, Fl27 load of ATV polymer mixed micelles, the particle size, critical micelle concentration, drug loading content and release properties in vitro were studied by laser particle size analyzer （DLS）, steady state fluorescence spectrometer, UV spectrophotometer （UV）. Results ATV-PF micelles had superiorities over ATV - F micelles in drug loading content, stability and so on. From the drug release experiment in vitro, at 24h, contents of the mixed micelles drug release were significantly higher than Pluronic micelles and more completely. Conclusion Adding certain proportion of mPEG-b PLGA in preparation of ATV-loaded Pluronie mieelles can improve the properity of micelles to some extent, and has a potential application in the further.
出处
《河南大学学报（医学版）》
CAS
2015年第3期166-170,174,共6页
Journal of Henan University:Medical Science
基金
河南省教育厅科学技术研究重点项目(13A350054)
