心房颤动与离子通道重构研究进展

Research Progress of Atrial Fibrillation and Ion Channel Remodeling

心房颤动是临床上最常见的持续性快速性心律失常之一,可导致心力衰竭、脑栓塞、认知功能障碍等严重并发症,是中国老年人发病率、致残致死率较高的一种疾病。心房颤动的发生机制较为复杂,大量研究表明,心脏离子通道重构在心房颤动的发生和维持中发挥极其重要的作用。作用于离子通道的药物已广泛应用于临床,但其疗效欠佳,并发症较多。因此探索有效的离子通道药物,对预防心房颤动的发生,延缓心房颤动的进程,提高患者生活质量,延长患者寿命具有重大意义。

Atrial fibrillation is one of the most common clinical sustained tachyarrhythmia, which can cause serious complications like heart failure, cerebral embolism and cognitive impairment. It has a high morbidity, mortality and disability rate disease in seniors. The mechanism of atrial fibrillation is complex, and a large nmnber of studies have shown that cardiac ion channel remodeling plays an extremely important role in the occurrence and persistence of atrial fibrillation. The drugs located in ion channel targets have been used in atrial fibril- lation, which are still ineffective and cause further complications. This study explores the effective ion channel drugs that can prevent the oc- currence of atrial fibrillation, delay the development of atrial fibrillation, improve the quality of life and prolong the life span in patients.