摘要
血脂异常会导致心血管疾病风险增加,降脂可减少动脉粥样硬化及其并发症的发生发展。他汀类药物能有效降低低密度脂蛋白,然而,许多患者在低密度脂蛋白很低的情况下仍发生心血管事件,载脂蛋白C-Ⅲ有直接导致动脉粥样硬化的作用,促发炎症因子的表达释放,是心血管疾病独立危险因素,因而载脂蛋白C-Ⅲ抑制剂为心血管疾病的治疗提供新的干预方式。
Dyslipidemia can increase the risk of cardiovascular disease, and lowering lipids may reduce the development of atheroscle- rosis and its complications. Statins can reduce low density lipoprotein, however, many patients with cardiovascular events still occur with ca- ses of low density lipoprotein. Apolipoprotein C-Ⅲ has a direct role in causing atherosclerosis, and it can prove the release of inflammatory factors. Also, it is an independent risk factor for cardiovascular disease. Thus apolipoprotein C-Ⅲ inhibitors provide new interventions for the treatment of cardiovascular diseases.
出处
《心血管病学进展》
CAS
2015年第5期613-616,共4页
Advances in Cardiovascular Diseases
关键词
载脂蛋白C-Ⅲ
血脂调节
心血管疾病
apolipoprotein C- Ⅲ
lipid regulation
cardiovascular disease
