Junctate蛋白在心力衰竭中的研究进展

Research Development of Junctate Protein in Heart Failure

Junctate蛋白是在哺乳动物肌浆网/内质网膜上新发现的一种Ca2+结合蛋白,与兰尼碱受体相关联,是天冬氨酰β-羟化酶基因转录的五个家族成员之一。Junctate蛋白存在于多种细胞中,参与细胞内Ca2+浓度的调节。大量的动物实验观察到,过表达junctate蛋白会导致多种钙调控通道功能异常,持续过表达junctate蛋白还会导致心肌肥大、心律失常、心肌纤维化等病理改变,最终会出现心力衰竭。因此,junctate蛋白在心力衰竭中起了重要的作用,现将junctate蛋白在心力衰竭中的相关研究做一综述。

Junctate protein is a newly discovered Ca^2＋ binding protein in mammalian sarcoplasmic reticulum/endoplasmic reticulum membrane. It is associated with ryanodine receptor, which is one of the five members of the gene transcription of aspartate beta-hydroxylase family. Junctate protein is present in a variety of cells that is involved in the intracellular Ca^2＋ concentration regulation. In a large number of animal experiments, over expression of junctate protein can cause more calcium channel regulation dysfunction and pathological changes in cardiac hypertrophy, arrhythmias and myocardial fibrosis and ultimately result in heart failure. Due to the important role of junctate protein in heart failure, junctate protein studies in heart failure are reviewed.