炎症与心房颤动相关性的研究进展

Research Progress of Inflammation Associated with Atrial Fibrillation

心房颤动(Af)是临床最常见的心律失常之一。目前对Af及其并发症(最重要是血栓形成)的有效治疗仍然是当前心律失常治疗中最薄弱的环节。Af的发病机制尚不完全明确。近年来大量临床和基础研究均提示炎症参与了Af的发生和发展。炎症与各种病理过程有关,如氧化应激、细胞凋亡、纤维化和促进Af基质形成。炎症还与内皮功能障碍、血小板活化、凝血酶联激活相关,这些均参与血栓形成过程。现对炎性介质及抗炎药物在Af中可能的作用机制及与Af的相关性综述如下。

Atrial fibrillation （Af） is the most common clinically relevant arrhythmia, however the methods available for treating Af and its complications （ of which the most important is thrombogenesis）, as well as for assessing Af risk and underlying pathophysiology, are largely limited. Emerging clinical and basic evidence suggests that inflammation may contribute to both the occurrence/maintenance of Af. Inflammation is suggested to be linked to various pathological processes that promote Af substrate formation such as oxidative stress, apoptosis and fibrosis. Inflammation has also been associated with endothelial dysfunction, platelet activation and coagulation cascade activation, lead- ing to thrombogenesis. The role of inflammation and inflammatory biomarkers in the risk management and treatment of Af is reviewed in this article.