棘皮动物微管相关类蛋白与间变性淋巴瘤激酶在肺腺癌中的表达及意义

Expression and significance of echinoderm microtubule-associated protein-like 4 in lung adenocarcinoma

目的探讨2011年4月至2015年4月基础和临床研究关于棘皮动物微管相关类蛋白4与间变性淋巴瘤激酶(EML4-ALK)融合基因在肺腺癌中的表达特点及临床意义。方法通过万方医学网和贵州省数字图书馆数据库文献法查询,对5年来发表在国内的有关EML4-ALK的文献进行收集整理和分析。结果共收集符合纳入标准文献21篇,研究病例2 550例,总结发现在肺腺癌中,EML4-ALK的检出率为9.61%,不同检测方法检出结果存在一定差异。结论 EML4-ALK在肺腺癌中呈低表达趋势,与肺腺癌的发生、发展有关,可作为新的治疗靶点,但检测方法仍需进一步研究和优化。

Objective To investigate the expression and significance of echinoderm microtubule-associated protein- like 4 （EML4-ALK） fusion gene in lung adenocarcinoma through basal and clinical research in the recent five years. Methods The research was conducted through Wanfang Medicine Net and digital library data base of Guizhou to collect and analyze the documents published in China about EMIA-ALK in the recent five years. Results There were 21 documents meeting inclusion criteria and 2 550 cases were studied. In summary, it was found out that detection rate of EMIA-ALK in lung adenocareinoma was 9.61%, With different testing method to measure the results there exist certain differences. Conclusion EML4-ALK showed a trend of lower expression in lung adenocarcinoma, associated with the occurrence and development of lung adenocarcinoma, needs to be studied and optimized.