葛根素在健康志愿者的药代动力学

PHARMACOKINETICS OF PUERARIN IN HEALTHY VOLUNTEERS

本文应用反相高效液相色谱荧光检测法研究了7名健康志愿者单次静脉注射葛根素5mg/kg的药代动力学。药时曲线经计算机以非线性最小二乘法拟合,符合二室开放模型。健康志愿者的血药时间平均方程为Ct=28.42e^(-0.0758t)+11.47e^(0.0095t),主要动力学参数t1/2α=10.3±4.1min,t1/2β=74.0±11.1min,V_1=0.132±0.036 l/kg,CL=0.0032±0.0008 l/(k·min),MRT=1.28±0.10h。

The pharmacokinetics of puerarin was studied in 7 heal-thy volunteers after a single iv 5 mg/kg by RP-HPLC with fluorescencedetection. The plasma concentration-time data was fitted by the nonlinearregression automatic program and showed to be subjected to two-compar-tments open model. The plasma concentration-time average equation ofhealthy volunteers is Ct= 28. 42e^(-0.0758t)+11.47e^(-0.0095t), the importantparameters t1/2α=10. 3± 4. 1 min, t1/2β= 74.0±11.1 min, V_1=0.132± 0. 0361l/kg, CL=0.0032 ±0.0008 l/(kg·min), MRT= 1. 28±0. 10h;