表观扩散系数与乳腺浸润性导管癌预后因素的相关性分析

Correlations between MR apparent diffusion coefficient values and prognostic factors of breast invasive ductal carcinoma

目的通过ADC值的测量探讨DWI在乳腺浸润性导管癌预后评价中的临床应用价值。材料与方法分析47例病理证实为浸润性导管癌的患者病灶ADC值,并与预后因素进行对照分析。结果乳腺浸润性导管癌ADC平均值为(0.957±0.151)×10-3 mm2/s,组织学分级与ADC值间存在负相关关系(r=0.876,P=0.000);病灶>2 cm组平均ADC值低于≤2 cm组(t=2.600,P=0.013);淋巴结转移阳性组平均ADC值低于阴性组(t=4.123,P=0.000);ER及PR阳性组平均ADC值低于阴性组(t=3.557,P=0.003;t=3.599,P=0.002);HER-2阳性组平均ADC值低于阴性组,但差异无统计学意义(t=1.399,P=0.173)。结论 ADC值与乳腺浸润性导管癌部分预后因素存在相关性,它可能是评价乳腺浸润性导管癌预后的潜在参数。

Objective： To investigate correlations between apparent diffusion coefifcient （ADC） values of invasive ductal carcinoma （IDC） and prognostic factors. Materials and Methods：We examined 47 patients by magnetic resonance imaging （MRI） of breast with pathologically conifrmed IDC and measured the ADC values of each lesion. The mean ADC values were cross-check analyzed with the prognostic factors.Results：The mean ADC value was （0.957±0.151）×10^-3 mm^2/s. The mean ADC values of IDC showed inverse correlation with histological grades （r=0.876, P=0.000） and were signiifcantly lower in the cases with large tumor size （t=2.600, P=0.013）, axillary lymph nodes metastasis （t=4.123, P=0.000）, ER and PR positive expression （t=3.557, P=0.003. t=3.599, P=0.002）. HER-2 expression showed no significant correlation with ADC values （t=1.399, P=0.173）. Conclusions：The ADC values were correlated with some prognostic factors and might provide valuable information for the prognosis of IDC.