西妥昔单抗联合mFOLFOX6方案治疗结直肠癌肝转移20例

Cetuximab Combined with m FOLFOX6 Scheme Chemotherapy for Treating Colorectal Liver Metastases in 20 Cases

目的观察西妥昔单抗联合m FOLFOX6方案治疗结直肠癌肝转移的临床疗效。方法采用回顾性分析方法,选择2012年1月至2014年9月经组织病理学证实的结直肠癌肝转移患者40例,其中观察组(20例)采用西妥昔单抗联合m FOLFOX6化学治疗(简称化疗)方案治疗,对照组(20例)仅采用m FOLFOX6方案化疗。结果观察组完全缓解2例、部分缓解10例、稳定6例、进展2例,有效率60.00%;对照组分别为0例、7例、8例、5例,有效率为35.00%;观察组的临床有效率明显高于对照组(P<0.05)。两组患者临床主要的毒副反应包括皮疹、恶心呕吐、腹泻、过敏反应、白细胞减少、神经毒性等,临床对症处理,均未影响治疗,两组差异无统计学意义(P>0.05)。治疗后观察组生活质量评分为(25.48±4.84)分,低于对照组的(43.67±6.32)分(P<0.05)。结论西妥昔单抗联合m FOLFOX6方案治疗结肠癌肝转移的临床疗效显著,值得临床推广。

Objective To observe cetuximab combined mFOLFOX6 scheme, the clinical curative effect of chemotherapy treatment for col- orectal cancer liver metastasis. Methods Used regression analysis method, in January 2012 to September 2014 histopathology confirmed 40 cases of patients with liver metastases from colorectal cancer, the observation group （20 cases） with cetuximab combined mFOLFOX6 chemotherapy treatment; The control group （20 cases） with mFOLFOX6 scheme only chemotherapy. Results The clinical curative effect, observation group （20 cases） CR in 2 eases, PR for 10 cases, the SD for 6 cases, PD for 2 cases, RR was 60. 00%, the control group （20 cases） CR 0 cases, PR in 7 cases, the SD for 8 cases, PD for 5 cases, RR was 35.00%. The clinical effectiveness of observation group was obviously higher than that of control group （P 〈 0. 05）. Two groups of patients with clinically main adverse reactions include skin rashes, nausea, vomiting, liver function damage, neurotoxicity, hair loss, etc. Two groups of patients after clinical cure of adverse reaction, both influence for clinical treatment, two groups there was no statistically significant difference （P 〉 0. 05）. Treatment of life score in both groups, observation group of life score was （25.48±4.84）,the control group life score was （43.67 ±6.32）,the quality of life of the differences between two groups was statistically significant （P 〈 0. 05）. Conclusion cetuximab xidan resistance combined mFOLFOX6 scheme, the clinical curative effect of treatment for colon cancer liver metastasis is remarkable.