左氧氟沙星结合细节化护理预防慢性阑尾炎术后感染41例

Quinolones Combined with Detailed Care for the Prevention of Postoperative Infection after Chronic Appendicitis Surgery in 41 Cases

目的探讨喹诺酮类药物结合细化护理在预防慢性阑尾炎术后感染的临床疗效。方法将2013年2月至2014年11月收治的82例患者随机分为治疗组和对照组,各41例。对照组仅给予甲磺酸左氧氟沙星注射液预防及治疗术后感染,治疗组在此基础上结合细节化护理预防及治疗术后感染。结果治疗组总有效率为92.69%,优于对照组的70.73%(P<0.05)。治疗组治疗后炎症因子水平分别为CD4+(60.5±9.8)%,CD4+/CD8+(1.62±0.53),白细胞介素-6(IL-6)为(2.4±1.5)μmol/L,IL-8(1.3±1.2)μmol/L,肿瘤因子-α(TNF-α)(7.5±2.8)μmol/L,对照组分别为CD4+(50.1±10.2)%,CD4+/CD8+(1.85±0.38),IL-6(4.5±1.1)μmol/L,IL-8(2.9±1.4)μmol/L,TNF-α(13.6±3.6)μmol/L。治疗组CD4+水平显著高于对照组(P<0.05);治疗组CD4+/CD8+,IL-6,IL-8,TNF-α水平明显低于对照组(P<0.05)。结论甲磺酸左氧氟沙星结合细节化护理可有效预防慢性阑尾炎的术后感染,可减轻炎症对患者的影响。

Objective Exploring and analysing of quinolones combined with detailed evaluation of care in the prevention of chronic ap- pendicitis analysis of postoperative infection. Methods 82 cases of patients who suffered from chronic appendicitis in our hospital from February 2013 to November 2014 admissions were randomly divided into treatment group and observation group, 41 patients in observation group gave only quinolone prophylaxis and treatment of postoperative infection, while 41 patients in treatment group gave quinolones combined with detailed evaluation prophylaxis and treatment of postoperative infection. The effect of postoperative treatment and the in- flammatory factors in the patients of the two groups were measured and compared. Results The total efficiency of treatment group was 92.69% while observation group total effective rate was 70. 73%, the difference was statistically significant（ P 〈 0.05）. The level of inflammatory factors in treatment group after treatment were measured CD4^＋ was （60. 5 ±9.8）%,CD4^＋/CD8^＋ was （1.62±0.53）, IL-6 was （2.4 ± 1.5 ） μmol/L, IL - 8 was （ 1.3 ± 1.2） μmol/L, TNF - α was （7.5 ± 2.8） μmol/L, respectively. The level of inflammatory factors in observation group after treatment were measured CD4^＋ was （50.1±10.2）%, CD4^＋/CD8^＋ was （1.85±0.38）, IL-6 was （4.5 ± 1. 1 ） μmol/L, IL - 8 was （2.9 ± 1.4） μmol/L, TNF - α was （13.6 ± 3.6） μmol/L, respectively. The results were compared discovery, CD4^＋ levels in patients of treatment group were significantly higher than CD4^＋ levels observation group of patients, the difference was statistically significant（ P 〈 0.05）. The level of CD4^＋/CD8^＋, IL-6, IL-8 and TNF-ct in treatment group were significantly lower than The level of CD4＋/CD8^＋, IL-6, IL- 8 and TNF- α in treatment group, the difference was statistically significant（ P 〈 0. 05）. Conclusion Quinolones combined with detailed evaluation of care to be effective in preventing chronic infections after appendectomy, and to reduced the effects of inflammation in the patient＇s body, so this treatment methods can be used in clinical.