甲状腺乳头状癌中STIP1、ER-α的表达及其意义

Expression and significance of STIP1 and ER-α in papillary thyroid carcinomas

目的探讨磷酸化应激诱导蛋白1(stress induced phosphoprotein 1,STIP1)和雌激素受体-α(estrogen receptor-α,ER-α)蛋白在甲状腺乳头状癌中的表达及其相关性。方法收集甲状腺乳头状癌54例、淋巴结转移癌18例、桥本甲状腺炎15例、癌旁甲状腺组织10例。应用免疫组化SP法检测各组STIP1和ER-α蛋白的表达,分析二者与甲状腺乳头状癌临床病理特征的关系及其相关性。结果 STIP1和ER-α在甲状腺乳头状癌中的阳性率(55.6%、44.4%)高于正常甲状腺组织(10%、0)及桥本甲状腺炎组织(8.3%、0,P均<0.05)。乳头状癌组织中STIP1蛋白表达与淋巴结转移相关(P<0.05),ER-α蛋白表达与患者性别、TG-Ab值、是否合并结节性甲状腺肿相关(P均<0.05),与淋巴结转移无关(P>0.05)。STIP1和ER-α蛋白表达与患者年龄、肿瘤部位、病灶数目、肿瘤大小、侵犯被膜、是否合并桥本甲状腺炎、TPO-Ab值均无关(P均>0.05);STIP1与ER-α表达呈正相关(P<0.05)。结论 STIP1和ER-α蛋白可能参与促进甲状腺乳头状癌的淋巴结转移。

Purpose To detect the expressions of stress induced phosphoprotein 1 （STIP1） and estrogen receptor-α（ER-α） in papil-lary thyroid carcinoma and to analyse the relationship between STIP1 and ER-α. Methods 54 cases of paraffin-embedded tissues of papillary thyroid carcinoma, 18 cases of papillary thyroid carcinoma with lymph node metastasis, 15 cases of Hashimoto’ s thyroiditis, 10 cases of adjacent normal thyroid tissue were collected. The expressions of STIP1 and ER-αwere detected by immunohistochemistry, and the relationship between the expressions and clinicopathological features of papillary thyroid carcinoma was analyzed. Results The expression of STIP1 and ER-α in papillary thyroid cancer group （ 55. 6% and 44. 4%） were higher than that of normal thyroid group （10% and 0） and Hashimoto’s thyroiditis group （8. 3% and 0, all P〈0. 05）. STIP1 expressions was related to lymph node metastasis （ P〈0. 05 ） , while ER-α expression was related to gender, TG-Ab and the merger of nodular goiter, but not related to lymph node metastasis （P〉0. 05）. The expressions of STIP1 and ER-α in papillary thyroid carcinoma were not related to patients’ age , tumor location, number of tumors, tumer size, invasion of capsule, the concomitant Hashimoto’ s thyroiditis and TPO-Ab （ all P〉0. 05）. And the expressions of STIP1 was not related to gender, TG-Ab and the merger of nodular goiter （all P〉0. 05）. A positive correlation was found between the expressions of STIP1 and ER-αin thyroid papillary carcinoma （P〈0. 05）. Conclusion STIP1 and ER-α in papillary thyroid carcinoma may be related with lymph node metastasis.