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胰腺实性-假乳头状肿瘤11例临床病理分析 被引量：6

Clinical pathological analysis of 11 cases of pancreatic solid-pseudopapillary tumors
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摘要 目的：探讨胰腺实性-假乳头状肿瘤（ solid-pseudopapillary tumor, SPPT）的临床病理特点、诊断及组织起源。方法复习相关文献,并回顾性分析11例SPPT的临床资料、病理组织学及免疫表型特征。结果11例SPPT中女性10例,男性1例,年龄17～60岁,平均33岁。肿瘤切面均为囊实性,有包膜,直径3.2～10.0 cm。镜下肿瘤由乳头区和囊实区混合组成,瘤细胞围绕纤维血管轴心形成特征性假乳头结构。免疫组化标记表达EMA （1/11）、vimentin （10/11）、NSE （11/11）、Syn （7/11）、CgA（1/11）、CD56（11/11）、CD10（11/11）、PR（9/11）、CD99（9/11）、α-AT（11/11）、β-catenin（11/11）、E-cadherin（11/11）、Cyc-lin D1（11/11）、c-Myc（11/11）。6例获得随访,随访时间20～112个月,均无肿瘤复发及转移,并存活至今。结论 SPPT是一种好发于年轻女性,具有低度恶性潜能的少见胰腺肿瘤,可能来源于多能干细胞,其发生与β-catenin通路关系密切；病理形态特征和免疫组化标记对SPPT的诊断和鉴别诊断具有重要价值。 Purpose To investigate the clinicopathlogic characteristic, diagnosis and histogenesis of pancreatic solid-pseudopapillary tumors （ SPPT） . Methods Combined with relevant literature, the clinical history, histopathological features and immunohistochemi-cal characteristics were analyzed in 11 cases of SPPT. Results There were 10 female patients and only 1 male in total 11 cases, aged from1 7 to 60 years （mean 33）. The sizes of tumors were from 3. 2 to 10. 0 cm. Histologically, they were composed of papillary and microcysticsolid structures. Pseudopapillary with a fibrovascular core was remarkable. Immunohistochemically, the tumors expressed EMA （1/11）, vimentin （10/11）, NSE （11/11）, Syn （7/11）, CgA （1/11）, CD56 （11/11）, CD10 （11/11）, PR （9/11）, CD99 （9/11）,α-AT （11/11）,β-catenin （11/11）, E-cadherin （11/11）, Cyclin D1 （11/11）, c-Myc （11/11）. 6 patients were followed up for a period of 20 to 112 months, and they were all alive and had no recurrence and metastasis. Conclusions SPPT is a tumor with low malignancy of the pancreas that most frequently affect young females. SPPT may be derived from multipotent stem cells and closely related withβ-catenin signaling pathway. Pathological morphology and immunohistochemistry are very important to the diag-nosis and differential diagnosis of SPPT.
作者 黄曦 卢林明 汪向明 梅晶晶
机构地区 皖南医学院附属弋矶山医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2015年第9期1026-1030,共5页 Chinese Journal of Clinical and Experimental Pathology
关键词 胰腺实性-假乳头状肿瘤 β-catenin通路 免疫组织化学 solid-pseudopapillary tumor β-catenin signaling pathway immunohistochemistry
分类号 R735.9 [医药卫生—肿瘤]
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参考文献15

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二级参考文献41

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共引文献43

同被引文献33

引证文献6

二级引证文献17

临床与实验病理学杂志
2015年 第9期

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