整体整合生理学医学新理论体系概论Ⅰ：呼吸调控新视野

New theory of holistic integrative physiology and medicine Ⅰ:New insight of mechanism of control and regulation of breathing

目的:以人为理解的功能为基础划分的系统生理学,在讨论呼吸调控时主要考虑呼吸系统本身,很少涉及其他系统,存在着明显的局限性和片面性。人是有机整体,应该从整体的角度探讨生命表征呼吸的调控。方法:以整体论为指导,打破功能系统的限制,构建整体整合生理学医学理论人体生命功能一体化调控的的基本框架。结果:除了动脉血气信号平均值参与呼吸调控外,其波浪式信号同样参与呼吸调控,并且是呼吸调控(切换)的核心,循环、神经和代谢等都是呼吸调控环路不可或缺的重要组成部分,这些新观点有助于对一些生理学和医学领域一直无法解释的难题作出合理的解释,比如:胎儿为什么不呼吸?为什么独立生命自始至终必须呼吸?第一次呼吸是如何产生的?呼吸节律和频率的产生?呼吸切换是如何实现的?循环功能如何影响呼吸等。结论:呼吸,生命之表征,是通过呼吸、循环、神经、代谢和消化吸收泌尿排泄等功能一体化调控实现的。

Objective： The modern systemic physiology, based on limit-understand functional classification, has significant limitation and one-sidedness. Human being is organic; we should approach the mechanism of control and regulation of breathing integrating all the systems. Methods： We use new theory of holistic integrative physiology and medicine to explain the mechanism of control and regulation of breathing. Results： Except the mean level information, the up-down ＂W＂ waveform information of arterial blood gas （ABG） is core signal to control and regulate breathing. In order to do so, we must integrate all systems together. New theory will help to explain some unanswered questions in physiology and medicine, for example： fetal does not breathing; how first breath generate; how respiratory rhythm and frequency generate, etc. Conclusion： Breathing is the sign of life. Mechanism of control and regulation of breathing has to integrate respiration, circulation, nerves, metabolism, exercise, sleep and digestion, absorption and elimination and etc altogether.