整体整合生理学医学新理论体系概论Ⅱ：循环调控新视野

New theory of holistic integrative physiology and medicine Ⅱ:New insight of the control and regulation of circulation

目的:传统系统生理学对于循环调控的解读仅就血液循环单一系统而言,而基本不考虑其他系统,必然有一定的片面性和局限性。人体是有机整体,只有从整体对循环功能调控分析才能更深入。方法:在整体整合生理学医学理论体系的指导下,以循环功能的目的为切入点,对其调控机制进行探讨。结果:血液循环的目的主要是为细胞新陈代谢运输所需的呼吸气体和消化吸收营养物质及排出代谢产物。围绕这个目的,为适应新陈代谢的静息、运动和睡眠状态变化,在神经体液调控下,与呼吸消化吸收泌尿排泄等所有系统共同配合从而实现循环功能调控。在此基础上,对许多问题给出了合理的解释,比如:出生后卵圆孔如何关闭、心力衰竭患者出现陈-施呼吸的机制、正常人心率、收缩压和自主张力变异的原始诱因、运动期间血流再分布机制等。结论:循环功能的目的是机体所有系统一体化调控共同参与实现的,而循环功能正常又是其他所有功能正常的前提。

Objective： The interpretation of control and regulation of circulatory parameters in traditional physiology has some limitations. Human being is an organic, circulatory control and regulation should involve all the systems. Methods： Based upon the theory of holistic integrative physiology and medicine, we approach to explain the circulatory control and regulation from its purpose. Results： The main purpose of circulation is to maintain a stable metabolism of cells, i.e. transport oxygen （from lung） and nutrients （from gastrointestinal tract） to cells, and return carbon dioxide and metabolic products back for elimination. Based on this goal, all respiration and gastrointesti- nal digestion, absorption, urinary excretion, etc. are integrative together for regulation to maintain the supply-demand balance at any metabolic status of resting, exercise and sleep. So that, we can explain many existing problems and ques- tions, for example： why and how the foramen ovale closed after birth; mechanism of Cheyne-Stokes respiration; blood flow redistribution during exercise; variabilities of systolic blood pressure, heart rate and autonomic tone. Conclusion ： The circulatory control and regulation is the integration of all systems of the body.