建立正常人肺血管容量的无创精确测量方法的初步报告

Preliminary reports of noninvasive accurate method to measure pulmonary vascular capacity in normal volunteers

目的：由于传统呼吸调控环路忽略了对血液循环的决定性作用,肺（静脉）血管容量相关研究甚少,亟需建立肺血管容量测量方法。方法：选择正常志愿者完成CT全肺扫描,图像数据经过计算机软件分析处理,从肺尖到肺底以40~50层进行肺野手工切划,相邻层间由计算机自动模拟连接,在去除干扰后进行全肺血管（≥0.6 mm）高精度三维立体成像技术处理,进而计算全肺和肺血管容积。结果：12例正常志愿者从肺尖到肺底CT扫描图片层数为530±98（431~841）张。全肺和肺血管的总容积是3705±857（2398~5383）ml,肺血管血液总的容积是125±32（94~201）ml。按肺静脉系统血管容量约为全肺血管血液容量一半计算,应该是63±16（47~100）ml。结论：肺CT扫描数据分析三维立体成像建立肺血管容量无创测量方法精确可行。

Objective： Because the traditional loop of breathing control and regulation effect on blood circulation, there was rare study of pulmonary vein capacity.We need a noninvasive and accurate pulmonary vascular capacity measurement and analysis method. Methods： Twelve normal volunteers were performed a total lung CT scan, image data analysis processing by computer software, the whole lungs from the apex to the base of lung with 40N50 layers by hand-cut, the connection between adjacent layers automatically by a computer simulation, the full pulmonary vascular （〉0.6 mm） were treated by high-accuracy three-dimensional imaging technology after removing the interference, and then calculate the whole lung and pulmonary vascular. Results： The whole lung of the 12 normal volunteers from the apex to the base of lung CT scan image layers was 530±98 （range, 431-841）. The total capacity of lung and pulmonary vascular blood was 3705±857 （range, 2398-5383） ml, and the total volume of the pulmonary vascular blood was 125±32 （range, 94-201） ml. The pulmonary vein vascular blood volume was 63±16 （range, 47-100） ml. Conclusion： The method of measuring the three-dimensional imaging of pulmonary vascular capacity by analyzing lung CT scan data is available and accurate.