冠状动脉病变SYNTAX评分与冠心病易患因素的相关性研究

The Relationship between SYNTAX Score of Coronary Lesions and Risk Factors of Coronary Heart Disease

目的探讨冠状动脉粥样硬化性心脏病(冠心病)患者冠状动脉病变SYNTAX评分与冠心病易患因素的相关性。方法选取2011年4月至2013年4月驻马店市第一人民医院收治的117例冠心病患者为研究对象,依据患者SYNTAX评分分为低危组(31例)、中危组(37例)和高危组(49例)。采用Spearman秩相关分析和多元逐步回归分析探讨冠状动脉病变SYNTAX评分与冠心病易患因素的相关性。结果高危组患者吸烟率、糖尿病率、高血压率、三酰甘油、同型半胱氨酸水平均显著高于中危组[69.4%(34/49)比56.8%(21/37),48.9%(24/49)比35.1%(13/37),46.9%(23/49)比32.4%(12/37),(2.0±1.0)mmol/L比(1.8±0.9)mmol/L,(37±9)μmol/L比(24±8)μmol/L]、低危组[48.4%(15/31),22.6%(7/31),12.9%(4/31),(1.8±0.9)mmol/L,(16±7)μmol/L],差异有统计学意义(P<0.05),且中危组患者上述指标均高于低危组,差异有统计学意义(P<0.05)。多元线性回归分析结果提示高血压、吸烟和血浆同型半胱氨酸水平为冠心病患者冠状动脉病变SYNTAX评分的主要影响因素(P=0.001,0.009,0.014)。结论冠心病患者冠状动脉病变SYNTAX评分的主要影响因素有血浆同型半胱氨酸水平、血压、吸烟,其中,同型半胱氨酸水平越高,血压升高程度越明显,患者出现冠状动脉病变的风险越大。

Objective To explore the correlation between coronary artery SYNTAX score and risk factors of coronary heart disease. Methods A total of 117 patients with coronary heart disease in Zhumadian City First People＇s Hospital from Apr. 2011 to Apr. 2013 were selected,according to SYNTAX score,the patients were divided into the low risk group（ 31 cases）,medium risk group（ 37 cases） and high risk group（ 49 cases）. Spearman rank correlation analysis and multivariate stepwise regression were used to analyze the relationships between SYNTAX coronary artery score and risk factors for coronary heart disease. Results Smoking rate,diabetes mellitus,high blood pressure,triglyceride and homocysteine of the high risk group were significantly higher than the medium risk group[69. 4%（ 34 /49） vs 56. 8%（ 21 /37）,48. 9%（ 24 /49）vs 35. 1%（ 13 /37）,46. 9%（ 23 /49） vs 32. 4%（ 12 /37）,（ 2. 0 ± 1. 0） mmol / L vs（ 1. 8 ± 0. 9） mmol / L,（ 37 ± 9） μmol/L vs（ 24 ± 8） μmol/L]and the low risk group[48. 4%（ 15 /31）,22. 6%（ 7 /31）,12. 9%（ 4 /31）,（ 1. 8 ± 0. 9） mmol/L,（ 16 ± 7） μmol/L]（ P〈0. 05）. Smoking rate,diabetes mellitus,high blood pressure,triglyceride and homocysteine of the medium risk group were significantly higher than the low risk group（ P〈0. 05）. Multiple stepwise regression analysis results suggested that hypertension,smoking and homocysteine were the main influencing factors of SYNTAX score of coronary artery lesion（ P = 0. 001,0. 009,0. 014）. Conclusion Plasma homocysteine,hypertension,smoking are main influencing factors of SYNTAX scores of coronary heart disease,the higher the level of homocysteine and blood pressure,the higher the risk of occurrence of coronary artery lesion.