正交试验优选藏药六味大托叶云实散中挥发油的包合工艺

Optimization of the Inclusion Technology for Volatile Oil from Liuwei Datuoyeyunshi Powder By Orthogonal Experment

目的:探讨六味大托叶云实散中肉桂、豆蔻和荜茇的混合挥发油包合工艺。方法:采用正交设计,以包合物收率和包合率综合评分为指标,考察挥发油与β-环糊精比例、包合温度、包合时间等3个因素对包合工艺的影响。结果:最佳包合工艺为挥发油与β-环糊精的比例为1∶6(V∶m),40℃搅拌包合90min。结论:优选的包合工艺合理、可行,可为六味大托叶云实散的二次开发提供参考。

Objective To optimize the inclusion technology of volatile oil compounds of Cinnamomi cortex, Amomi fructus rotum- dus and Piperis longi fructus in Liuwei Datuoyeyunshi Povder. Methods The inclusion technology was optimized by orthogonal design with the ratio of volatile oil to β - cyclodextrin, inclusion temperature and inclusion time as factors using utilization ratio of volatile oil and the yield of inclusion compound as index. Results The optimal inclusion conditions were： applying the saturated aqueous solution method, the proportion of volatile oil to β- cyclodextrin was 1： 6 （ V： m）, lasting 90 minutes at 40℃. Conclusion The inclusion tech- nology of volatile oil is reasonable, feasible, and suitable for industrial production.