Nd:YAG激光联合康复新液治疗糜烂型OLP疗效纵向观察

Longitudinal Observation on the Efficacy of Pulsed Nd:YAG Laser with Kangfuxin Solution in the Treatment of Erosive Oral Lichen Planus

目的:评价Nd:YAG激光联合康复新液治疗糜烂型口腔扁平苔藓的纵向疗效。方法:对121例临床经病理确诊的口腔糜烂型扁平苔藓患者随机分为两组,A组41例,使用Nd:YAG激光局部照射联合康复新液湿敷治疗;B组40例,采取康复新液局部湿敷治疗;C组40例,单纯使用Nd:YAG激光局部照射治疗。3组均定期随访24月,进行统计学分析。结果:3组病例于治疗后2周、1月、6月、24月给予疗效评定。实验A组与B、C两组治疗后2周与1月相比,复发率差异无显著性,显效率差异有统计学意义(P<0.05);治疗后6月及24月实验A组与B、C两组显效率和复发率比较均有统计学意义(P<0.05)。结论:在合适的照射频率、照射角度、照射时间下,脉冲Nd:YAG激光联合康复新液治疗糜烂型扁平苔藓可以迅速达到治疗效果,控制远期复发,提高治愈成功率。

Objective： To evaluate the longitudinal curative effect of pulsed Nd：YAG laser with Kangfuxin solution in the treatment of erosive oral lichen planus （OLP）. Methods： An open trial included 121 erosive OLP patients. All patients were randomly divided into three groups： group A （41 patients） was treated with Nd： YAG laser and Kangfuxin solution; group B （40 patients） was treated with Kangfuxin Solution; Group C （40 patients） were trea- ted by local irradiation of Nd：YAG laser. The clinical efficacy was evaluated 24 months after the treatment. Resuits.. There was no significant difference in the recurrent rate between group A, B and C immediate and one month after treatment, however, significant difference in the clinical effective rate （P〈0.05）. There was a significant difference in both the clinical effective rate and recurrent rate among three groups 6 and 24 months after treatment （P〈0.05）. Conclusion.. Under appropriate irradiation frequency, irradiation angle and exposure time, combination of pulsed Nd：YG laser with Kangfuxin solution has a quick therapeutic effect in the treatment of erosive OLP, with low recurrent rate and high cure rate .