期刊文献+

卒中后认知损害与动脉硬化因子的相关性研究 被引量:1

The correlation between post-stroke cognitive impairment and the arteriosclerosis factors
下载PDF
导出
摘要 目的评价卒中后认知功能与动脉硬化因子的相关性。方法选取103例就诊患者,根据卒中后有无认知损害分组,纳入卒中后认知损害(CIAS)组(n=54)和卒中后无认知损害(NCIAS)组(n=49)。分别测量血液中动脉硬化因子和踝臂指数(ABI)等,并比较两组之间的是否存在统计学差异。结果 CIAS组ABI显著低于NCIAS组(P=0.002),且卒中后认知损害可能与年龄增加、低密度脂蛋白胆固醇(LDL-C)水平增高及ABI降低有关。结论部分动脉硬化因子加重卒中后认知功能损害。 Objective To evaluate the relationship between post-stroke cognitive impairment and atheroscle-roticindicators.Methods 103casesofacuteischemicstrokepatientswereincludedanddividedintocognitiveim-pairment after stroke (CIAS) group (n=54) and non cognitive impairment after stroke (NCIAS) group (n=49)ac-cording to their cognition level.Serum arteriosclerotic indicators and ankle brachial index ( ABI) of two groups were analyzed.Results The ABI of CIAS group was (0.96 ±0.17)significantly lower than that of NCIAS group (1.05 ± 0.11) ( P=0.002);The post-stroke cognitive impairment correlated with increased with age ( OR=1.145,P=0.017) and elevated low density lipoprotein cholesterol levels (OR=46.933,P=0.033).Conclusion:The athero-sclerotic indicators have impacts on the declined post-stroke cognitive function.
出处 《中国临床保健杂志》 CAS 2015年第5期465-468,共4页 Chinese Journal of Clinical Healthcare
基金 北京市科委慢性病的二级预防研究(Z111107056811043) 高等学校学科创新引智基地计划(B08006) 北京中医药大学神经变性病创新团队项目(2011-CXTD-21)
关键词 卒中 认知障碍 动脉硬化 Stroke Cognition disorders Vascular stiffness
  • 相关文献

参考文献13

  • 1Rasquin SM, Verhey FR, van Oostenbrugge R J, et al. De- mographic and CT scan features related to cognitive im- pairment in the first year after stroke[ J]. J Neurol Neuro- surg Psychiatry ,2004,75 ( 11 ) : 1562-1567.
  • 2Greenland P, Abrams J, Aurigemma GP, et al. Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III[ J ]. Circulation,2000,101 ( 1 ) : E16-E22.
  • 3Van Exel E, Gussekloo J, Houx P, et al. Atherosclerosis and cognitive impairment are linked in the elderly. The leiden 85-plus study [ J ]. Atherosclerosis, 2002,165 ( 2 ) : 353 -359.
  • 4Ouriel K. Peripheral arterial disease [ J ]. Lancet, 2001, 358(9289) : 1257-1264.
  • 5Fowkes FG. The measurement of atherosclerotic peripheral arterial disease in epidemiological surveys [ J ]. Int J Epi- demiol,1988,17(2) : 248-254.
  • 6Heald CL, Fowkes FG, Murray GD, et al. Risk of mortality and cardiovascular disease associated with the ankle-bra- chial index : Systematic review[ J ]. Atheroselerosis ,2006, 189(1) : 61459.
  • 7Fowkes FG, Murray GD, Butcher I, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality : a meta-analysis [ J ]. JAMA,2008,300(2) : 197-208.
  • 8Guerchet M, Aboyans V, Nubukpo P, et al. Ankle-brachial index as a marker of cognitive impairment and dementia in general population. A systematic review [ J ]. Athero- sclerosis,2011,216(2) : 251-257.
  • 9Johnson W, Price JF, Rafnsson SB, et al. Ankle-brachial index predicts level of,but not change in, cognitive func- tion: the edinburgh artery study at the 15-year follow-up [J]. Vasc Med,2010,15(2) : 91-97.
  • 10Bums A, OBrien J, Auriacombe S, et al. Clinical practice with anti-dementia drugs: a consensus statement from british association for psychopharmacology [ J ]. J Psycho- pharmacol, 2006,20 ( 6 ) : 732-755.

同被引文献7

引证文献1

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部