卒中后认知损害与动脉硬化因子的相关性研究

The correlation between post-stroke cognitive impairment and the arteriosclerosis factors

目的评价卒中后认知功能与动脉硬化因子的相关性。方法选取103例就诊患者,根据卒中后有无认知损害分组,纳入卒中后认知损害(CIAS)组(n=54)和卒中后无认知损害(NCIAS)组(n=49)。分别测量血液中动脉硬化因子和踝臂指数(ABI)等,并比较两组之间的是否存在统计学差异。结果 CIAS组ABI显著低于NCIAS组(P=0.002),且卒中后认知损害可能与年龄增加、低密度脂蛋白胆固醇(LDL-C)水平增高及ABI降低有关。结论部分动脉硬化因子加重卒中后认知功能损害。

Objective To evaluate the relationship between post-stroke cognitive impairment and atheroscle-roticindicators.Methods 103casesofacuteischemicstrokepatientswereincludedanddividedintocognitiveim-pairment after stroke （CIAS） group （n=54） and non cognitive impairment after stroke （NCIAS） group （n=49）ac-cording to their cognition level.Serum arteriosclerotic indicators and ankle brachial index （ ABI） of two groups were analyzed.Results The ABI of CIAS group was （0.96 ＆#177;0.17）significantly lower than that of NCIAS group （1.05 ＆#177; 0.11） （ P=0.002）;The post-stroke cognitive impairment correlated with increased with age （ OR=1.145,P=0.017） and elevated low density lipoprotein cholesterol levels （OR=46.933,P=0.033）.Conclusion：The athero-sclerotic indicators have impacts on the declined post-stroke cognitive function.