非瓣膜性房颤合并脑梗死再发的相关因素分析

Analysis of related factors on patients with atrial fibrillation not due to valvular disease and recurrent cerebral infarction

目的探讨非瓣膜性房颤(NVAF)动患者复发脑梗死的危险因素。方法选择2009年12月至2012年12月在本院住院的NVAF患者130例,分为3组,分别为35例NVAF合并脑梗死(CI)复发组、52例NVAF合并CI未再复发组、43例NVAF未发CI组。对该三组中12个因素进行对比分析,并用多元Logistic回归分析各因素与复发组的关系,用多元相关分析各危险因素之间的相关性。结果 NVAF合并CI复发组的高龄(大于75岁)、附壁血栓史及糖尿病史比例明显高于初发组(P<0.017),多元Logistic回归分析显示高龄(大于75岁)(P=0.001)、附壁血栓史(P=0.006)及糖尿病史(P=0.000)是复发组的主要危险因素。多元相关分析显示该三项之间没有相关性。结论高龄(大于75岁)、附壁血栓史、糖尿病史是NVAF合并CI患者复发梗死的独立危险因素。

Objective To explore the risk factors of patients with atrial fibrillation not due to valvular disease and recurrent cerebral infarction. Methods Choosing 130 patients with atrial fibrillation were not due to valvular disease in hospital during Dec. 2009 to Dec. 2012, who were divided into three groups, 35 patients with atrial fibrillation were not due to valvular disease and recurrent cerebral infarction group（ recurrent group） ,52 patients with atrial fibrillation were not due to valvular disease and first cerebral infarction group （ first group） , 52 patients with atrial fibrillation were not due to valvular disease and without cerebral infarction group（ control group）. Contracting 12 factors of 3 groups aboved, analysising the relationship between the 12 factors with recurrence group by multiple Logistic regression analysis, and the correlation among various factors with multiple correlation analysis. Results The numbers of older age, Mural thrombus history and diabetes mellitus （ DM ） history were more in the recurrent group than the first group. The multivariate Logistic regression analysis showd that age （〉75 years） （P= 0.001 ）, and the history of mural thrombus （ P = 0.006 ）, history of diabetes （ P = 0.000） were major risk factors for recurrent group. Conclusion Age （ 〉 75years）, Mural thrombus history and DM history areindependent risk factors of the patients with atrial fibrillation were not due to valvular disease and recurrent cerebral infarction.