氧化纤维素增强胶原水凝胶

Oxidized Cellulose Enhanced Collagen Hydrogels

对纤维素进行氧化,得到醛基化的氧化纤维素,将其作为大分子交联剂制备了氧化纤维素改性胶原水凝胶.通过扫描电镜、力学性能及流变学测试,对改性胶原水凝胶的结构和性能进行了表征.研究结果表明,与纯胶原水凝胶相比,氧化纤维素改性胶原水凝胶的力学性能和热稳定性都得到了明显改善,其压缩破坏强度比纯胶原水凝胶提高了1个数量级以上.此外,氧化纤维素的引入,并未出现一般化学交联剂改性所带来的细胞毒性,并保持了胶原水凝胶良好的生物相容性.为改性胶原水凝胶在组织工程材料领域的应用提供依据.

Aldehyde-functionalized cellulose（ DAC） was obtained by the oxidization of cellulose,and was applied as a macromolecular crosslinker to modify the collagen（ Col） hydrogel. The structures and properties of oxidized cellulose modified collagen（ Col / DAC） hydrogels were characterized with SEM observation,mechanical test and rheology analysis. The results show that the mechanical properties and thermal stability of Col / DAC hydrogels are significantly improved compared to the pristine Col hydrogel,especially the breaking compression strength of Col / DAC hydrogel can be more than one order of magnitude higher than the pristine Col hydrogel. In addition,it is shown that introducing of oxidized cellulose does not bring the cytotoxicity that is often seen from the conventional chemical crosslinking method,and maintains the good biocompatibility of the final product. Therefore,such a biocompatible and strong collagen hydrogel obtained from the oxidized cellulose modification may have the great potential in tissue engineering and other biomedical fields.