清源生化汤对改善创伤后脓毒症患者淋巴细胞水平的影响

Qiangyuan Shenghua Decoction on Lymphocyte Level of Patients with Posttraumatic Sepsis

目的:研究中药清源生化汤对创伤后脓毒症患者淋巴细胞水平的影响。方法:88例创伤后脓毒症患者,随机平均分为治疗组和对照组。对照组使用西医常规治疗加服纯净水,治疗组在西医常规治疗基础上加服中药清源生化汤。两组患者均于治疗前、治疗后1,3,7 d抽取外周静脉血,监测白细胞计数(WBC),中性粒细胞数量(NEU),中性粒细胞百分含量(NEU%),总淋巴细胞计数(TLC),总淋巴细胞百分数(TLC%),C反应蛋白(CRP)和降钙素原(PCT)变化,观察治疗7 d后2组死亡率。结果:治疗前两组患者WBC,NEU,NEU%,TLC,TLC%,CRP和PCT比较无差异;治疗1 d后治疗组TLC较治疗前有统计学差异(P<0.05);治疗3 d后治疗组WBC,NEU,NEU%,TLC,TLC%,CRP,PCT与对照组NEU%,TLC,TLC%,CRP,PCT较治疗前有统计学差异(P<0.05),治疗组WBC,NEU%,TLC,TLC%,CRP和PCT与对照组比较有统计学差异(P<0.05);治疗7 d后治疗组,对照组全部指标较治疗前有统计学差异(P<0.05),且与对照组比较有统计学差异(P<0.05);两组死亡率比较,治疗组优于对照组(P<0.05)。结论:清源生化汤可改善脓毒症患者淋巴细胞水平和比例,且预后良好。

Objective： To research the effect of Qiangyuan Shenghua decoction on lymphocyte level of patients with posttraumatic sepsis. Method： Eighty-eight patients with posttraumatic sepsis were randomly divided into treatment group and control group. Patients in control group were treated with conventional western medicine and pure water, and patients in the treatment group were treated with Qingyuan Shenghua decoction in addition to the conventional western medicine therapy. The white blood cell count （WBC）, the number of neutrophils （NEU）, neutrophil percentage （NEU%）, total lymphocyte count （TLC） , total lymphocyte percentage （TLC%） and C-reactive protein （CRP） and calcitonin original （PCT） in venous blood of all the patients were detected on the 1st, 3rd and 7th day before and after treatment, and the mortality was also observed on the 7th day after treatment. Result： The difference on WBC, TLC, TLC% , NEU, NEU % , CRP and PCT between the two groups before and after treatment was not significant. After a day＇s treatment, the TLC in the treatment group was significantly different from before the treatment （P 〈 0. 05）. After 3 day＇s treatment, the WBC, NEU, NEU% , TLC and TLC% , CRP and PCT of patients in treatment and control group were significantly different from before the treatment （P 〈0. 05）, and the WBC, NEU, NEU% , TLC and TLC% , CRP and PCT in the treatment group were significantly different from that of the control group （P 〈 0.05）. After 7 day＇s treatment, all of the indexes of patients in treatment and control group were significantly different from before the treatment （P 〈 0.05） and that of the control group （P 〈 0.05 ）. The mortality of treatment group was less than that of control group （P 〈 0.05 ）. Conclusion： Qiangyuan Shenghua decoction could improve the lymphocyte level and lymphocyte ration, and the prognosis was favorable.