肠内营养支持治疗在重症急性胰腺炎中的应用进展

Research progress of enteral nutrition support for treating severe acute pancreatitis

目的重症急性胰腺炎是累及胰腺和全身其他器官的危重症，具有发病急、进展快、并发症多，病程长以及病死率高的特点。早期积极个体化综合治疗能改善预后。肠内营养治疗能保护肠黏膜屏障，减少肠道细菌和内毒素移位，可有效减少体内炎症细胞因子，降低全身炎性反应及继发感染，改善患者预后，是重症急性胰腺炎有效治疗方法之一。本研究就肠内营养治疗的支持途经、给予时机和营养制剂的研究进展进行综述。

Objective Severe acute pancreatitis is a critical disease involved the pancreas and other organs of the body with acute onset, rapid progress, more complications, long course of disease, high mortality rate. Early individualized comprehensive treatment can improve the prognosis. Enteral nutrition can maintain intestinal mucosal barrier, reduce the intestinal bacteria and endotoxin translocation, can effectively reduce the secretion of inflammatory cytokines in vivo, re- duce the systemic inflammatory response and secondary infection, improve the nutritional status of patients with severe acute pancreatitis, is one of effective treatment methods. In this paper, enteral nutrition support way, given timing and progres- sion of nutrition preparations are reviewed.