重组人生长激素对体外受精-胚胎移植失败患者第二周期妊娠结局的疗效分析

Analysis on the curative effect of recombinant human growth hormone on pregnancy outcome of the second cycle among patients failing in IVF- ET

目的探讨生长激素（GH）对前次体外受精一胚胎移植（IVF—ET）失败患者的疗效。方法选择2013年1～12月在南京市妇幼保健院生殖中心因前次IVF—ET失败再次行IVF治疗的不孕患者30例，均采用与前次相同的常规短方案超促排卵加用GH治疗为研究组，以自身前一次未加用GH者为对照组，采用自身对照的方法观察患者加用GH后的卵巢反应及妊娠结局。结果GH组移植周期26例，对照组移植周期27例。观察促性腺激素（Gn）用量、hCG注射日子宫内膜、E2水平、获卵数对照组和GH组间均无统计学差异（P〉0．05）。Gn使用时间、2PN受精数、优质胚胎数、种植率、妊娠率等观察指标，对照组显著低于GH组，有统计学差异（P〈0．05）。结论小剂量生长激素对前次IVF失败患者超促排卵治疗，可显著提高优质胚胎数、种植率和临床妊娠率。

Objective To explore the curative effect of recombinant human growth hormone （rhGH） on pregnancy outcome of pa- tients failing in the previous in vitro fertilization-embryo transfer （[VF-ET） cycle. Methods Thirty infertile patients treated by IVF after failing in the previous IVF-ET in this hospital from January to December in 2013 were selected, the patients in study group received routine short-term protocol controlled ovarian hyperstimulation （COH） and rhGH, while the patients in control group only received routine short- term protocol COH; a self-control study was conducted to observe ovarian responses and pregnancy outcomes in the two groups. Results There were 26 patients in study group and 27 patients in control group. There was no statistically significant difference in gonadotropin dose, endometrial thickness on the day of human chorionic gonadotropin （hCG） injection, estradiol level, the number of retrieved oocytes between the two groups （ P〉O. 05 ） . The utilization time of gonadotropin, the number of 2PN fertilization oocytes, the number of high quality embry- os, implantation rate, and pregnancy rate in control group were statistically significantly lower than those in study group （ P〈0. 05 ） . Con- clusion Low-dose rhGH can significantly improve the number of high quality embryos, implantation rate, and clinical pregnancy rate in the course of COH of the patients failing in the previous IVF.