多功能的Ⅰ型跨膜蛋白ESDN

ESDN Is A Multifunctional Type-Ⅰ Transmembrane Protein

内皮和平滑肌细胞来源的neuropilin样分子ESDN(endothelial and smooth muscle cell-derived neuropilin-like molecule)是在哺乳类动物中广泛存在的一类I型跨膜蛋白(type-I transmembrane protein)。ESDN由N-端长分泌信号序列、一个CUB(domain found in complement C1r/C1s、Uegf和Bmp1)结构域、一个LCCL(domain found in Limulus factor C、Coch和Lgl)结构域、一个凝血因子V/VIII同源结构域和一个长胞质尾部组成,在生物进化过程中相对保守。该文综述了ESDN蛋白的发现与分布及其结构特征,对ESDN参与血管再生调控的研究成果进行了较为详细的综述,同时介绍了ESDN在肿瘤发生、转移及免疫等方面作用的研究进展。

Endothelial and smooth muscle cell-derived neuropilin-like molecule （ESDN） is one of type-I Wansmembmne protein that is genetically conserved among various mammalian species. It consists of a N-terminal secretory signal sequence, a CUB structural domain, a LCCL structural domain, a coagulation factor V/VⅢ homology domain and a long cytoplasmic tail. It is relatively conservative in the process of biological evolution. This ESDN molecule confer diverse and sophisticated functions, thus to modulate vascular remodeling, influence tumor metastasis, immune regulation, etc. The structure, distribution, as well as the affected physiological functions are summarized in this review.