海藻酸钠/聚乙二醇改性微球的研究

Research on SA/PEG modified microsphere materials

通过海藻酸钠/聚乙二醇(SA/PEG)改性微球实验,研究了改性微球的最佳浓度配比、溶胀性能、凝胶化速率、干燥速率、含水率、载药量及体外释药性能。结果表明:海藻酸钠(SA)浓度为3%,氯化钙浓度为4%时,微球成球效果最佳。SA浓度、氯化钙溶液浓度、PEG浓度、投药量的不同影响微球的载药量;在模型药物盐酸四环素的用量固定在0.2000g的条件下,采用实验(SA 3.0%;PEG 0.0%,0.5%,1.0%,1.5%,2.0%;氯化钙4%),通过测得的含水率、载药率和释放率,综合分析选择最合适浓度:SA 3%,氯化钙4%。随着PEG浓度的增加,微球的含水率降低;溶胀速率加快;并且微球能在pH=7.4的PBS磷酸缓冲液中溶胀。

Through the experiment of SA/PEG modified microspheres,best concentration ratio,swelling properties, gelation rate,drying rate,moisture content,drug-polymer interactions,and in vitro drug release performance were studied. The results ： when the concentration of sodium alginate was 3 %, the concentration of calcium chloride was 4 %, the balling effect was the best. The concentration of sodium alginate,calcium chloride solution,PEG and the quantity of reagent influenced the drug loadings of microspheres. In the dosage of the drug tetracycline hydrochloride fixed model under the condition of 0.2000g, using the experimental（SA 3.0%; PEG 0.0%,0.5%, 1.0%, 1.5%, 2.0%, calcium chloride 4%）. Through the moisture content, drug-loading rate, release rate, comprehensive analysis to choose the most suitable concentra- tion： SA 3.0 %, calcium chloride 4 %. With the increase of concentration of polyethylene glycol, the moisture content of mi crospheres decreased, the swelling rate accelerated. And microspheres can swelling in in pH= 7.4 buffer.