他汀类药物引起相关性肌病不良反应的调查分析

Investigation and analysis of adverse reactions of related myopathy caused by statins

目的对他汀类药物诱发相关性疾病的不良反应情况进行分析与研究。方法选取我院2013年5月~2014年5月所收治的80例他汀类药物所致相关性肌病不良反应患者作为研究对象,对其临床资料进行回顾性分析,即对引起相关性肌病不良反应的药物以及具体不良反应情况进行探究。结果他汀类药物所致相关性肌病不良反应患者中,男性与女性发生率比较,差异无统计学意义（56.25%比43.75%,P〉0.05）;年龄在60岁以上的患者,其相关性肌病不良反应的发生率最高（63.75%）;9例肌痛（11.25%）,均服用了辛伐他汀药物;23例肌炎（28.75%）,其中有12例服用了辛伐他汀,9例服用了阿托伐他汀,2例服用了普伐他汀;48例横纹肌溶解症（60.00%）,其中有33例服用了辛伐他汀,8例服用了洛伐他汀,4例服用了阿托伐他汀,2例服用了氟伐他汀,1例服用了普伐他汀。结论服用如辛伐他汀等他汀类药物后,患者可能会出现相关性肌病不良反应,尤其是老年患者,对此应采取积极有效的措施,以最大限度地预防相关性肌病的发生,提高治疗效果。

Objective To analyze and study the adverse reactions of related myopathy caused by statins. Methods From May 2013 to May 2014,80 patients who were suffered from statins-induced adverse reactions of related myopathy and admitted into our hospital were selected as research objects.Their clinical data were retrospectively analyzed in or- der to explore the drug causing adverse reactions of related myopathy and specific adverse reactions. Results There was no statistical difference in gender of male （56.25%） and female （43.75%） （P〉0.05）.Patients aged over 60 years old ob- tained the highest incidence of adverse reactions of related myopathy,which was 63.75%.There were 9 cases （11.25%） patients in myalgia and were all administered with Simvastatin.23 cases （28.75%） patients were presented with myositis, among them,12 cases taking Simvastatin,9 cases taking Atorvastatin,and 2 cases by Pravastatin.Adverse reaction of rhabdomyolysis was in 48 cases （60.00%） patients,of whom 33 patients were administered with Simvastatin,8 cases with Lovastatin,4 cases with Atorvastatin,2 cases with Fluvastatin,and one with Pravastatin. Conclusion After taking statins like Simvastatin,patients may occur with adverse reactions of related myopathy,especially in the elderly ones.Therefore, effective measures should be actively taken aiming at preventing occurrence of related myopathy at uttermost and im- proving therapeutic effect.