丹参注射液辅佐神经节苷酯治疗新生儿缺氧缺血性脑病的临床分析

Clinical analysis of Danshen injection assisted ganglioside in the treatment of neonatal hypoxic-ischemic encephalopathy

目的 分析丹参注射液辅佐神经节苷脂治疗新生儿缺氧缺血性脑病的治疗效果。方法 选择2012年10月~2014年10月在我院就诊的患有缺氧缺血性脑病的新生儿74例,随机分为对照组和治疗组,每组37例。单纯应用神经节苷酯对对照组患儿实施治疗;采用神经节苷酯与丹参注射液联合对治疗组患儿实施治疗。对比两组患儿用药治疗前后新生儿神经行为测定（NBNA）评分的改善幅度、意识状态恢复时间、肌张力水平异常持续时间、药物治疗计划实施总时间、缺氧缺血性脑病治疗效果、药物治疗期间出现不良反应的人数。结果 治疗组患儿用药治疗前后NBNA评分的改善幅度明显大于对照组,差异有统计学意义（P〈0.05）;意识状态恢复时间、肌张力水平异常持续时间、药物治疗计划实施总时间明显短于对照组,差异有统计学意义（P〈0.05）;缺氧缺血性脑病治疗效果明显优于对照组,差异有统计学意义（P〈0.05）;药物治疗期间出现不良反应的人数明显少于对照组,差异有统计学意义（P〈0.05）。结论 神经节苷酯联合丹参注射液治疗缺氧缺血性脑病新生儿,临床效果显著。

Objective To analyze the treatment effects of Danshen injection assisted ganglioside in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods Seventy-four neonates diagnosed with hypoxic-ischemic encephalopathy in our hospital from October 2012 to October 2014 were selected and randomly divided into control group and treatment group,with 37 patients in each group.The control group was given simple ganglioside treatment and the treatment group was given ganglioside combined with Danshen injection treatment.The improvement degree,conscious state recovery time,duration of abnormal muscular tone levels,total implementation time of drug treatment plan,treatment effects of hypoxic-ischemic encephalopathy and number of people with adverse reactions during drug treatment between two groups before and after drug treatment was compared respectively. Results The treatment group was significantly higher than the control group in the improvement degree of NBNA score between before and after drug treatment,with statistical difference（P〈0.05）.The treatment group was significantly shorter than the control group in the conscious state recovery time,duration of abnormal muscular tone levels and total implementation time of drug treatment plan,with sta- tistical difference（P〈0.05）.The treatment group was significantly better than the control group in the treatment effects of hypoxic-ischemic eneephalopathy,with statistical difference （P〈0.05）.The treatment group was significantly smaller than the eontrol group in the number of people with adverse reactions during drug treatment,with statistieal differenee （P〈 0.05）. Conclusion The application of ganglioside combined with Danshen injection shows highly significant clinical effects in the treatment of neonates with hypoxic-isehemie encephalopathy.