含胃铋镁四联疗法根除幽门螺杆菌的疗效观察

Curative effect observation of quadruple therapy containing bismuth magnesium for eradication of Helicobacter pylori

目的观察含胃铋镁四联疗法根除幽门螺杆菌(Hp)的临床疗效。方法选择2014年10月~2015年3月孝感市中心医院经^(13)C-尿素呼气试验确诊的96例Hp感染患者为研究对象,随机分为治疗组和对照组,各48例。治疗组给予含胃铋镁四联疗法;对照组给予胶体酒石酸铋四联疗法,疗程为14 d。比较两组的Hp根除效果及不良反应发生率。结果治疗组的Hp根除率(85.42%)高于对照组(83.33%),差异无统计学意义(P>0.05)。治疗组和对照组的不良反应发生率分别为6.25%、20.83%,差异有统计学意义(P<0.05)。结论含胃铋镁四联疗法对Hp根除效果显著,且安全性高,值得临床推广。

Objective To observe clinical curative effect of quadruple therapy containing bismuth magnesium for eradication of Helicobacter pylori （Hp）. Methods 96 Hp-infected patients confirmed by 13C-urea breath test in Xiaogan Central Hospital from October 2014 to March 2015 were selected as study objects,and the were randomly divided into treatment group and control group,and there were 48 cases in each group.Treatment group was given quadruple therapy containing bismuth magnesium,and control group was given colloidal bismuth tartrate-containing quadruple therapy.Hp eradication effect and the incidence rate of adverse reaction was compared respectively between two groups. Results Hp eradication rate of treatment group （85.42%） was higher than that of control group （83.33%）,and there was no sta- tistical difference （P〉O.05）. The incidence rate of adverse reaction in treatment group and control group was 6.25% and 20.83% respectively,and there was a statistical difference （P〈0.05）. Conclusion Quadruple therapy containing bismuth magnesium has significant effect of Hp eradication and higher security.It is worthy of clinical promotion.